Gold Standard Physiological Measurements and Novel Drug Delivery Methods

Gold Standard Physiological Measurements and Novel Drug Delivery Methods

A 2-part webinar for scientists interested in novel drug delivery methods for basic research, drug discovery and development. Learn about novel infusion technologies and how challenges in physiological monitoring and drug delivery are being overcome by implantable and programmable devices.

Gold Standard Physiological Monitoring With Novel Infusion Technology: Quality Data in Mice to Marmosets.

Christian Schnell, Lab Head of in-vivo Pharmacology and Oncology Research at Novartis in Basel, Switzerland presents data from multiple species that show how differences in blood pressure, heart rate and acute stress impact drug activity and how dosing a pre-trained animal can influence hemodynamic parameters.

Synthetic, Structural, and Mechanistic Investigations of Vitamin B12 Conjugates of the Anorectic Peptide PYY3-36.

Dr. Doyle discusses how vitamin B12 conjugation of Peptide YY3-16 decreases food intake compared to native Peptide – YY3-36. Learn how challenges to peptide-based therapies, such as rapid clearance, ready degradation by hydrolysis/proteolysis and poor uptake can be overcome by using the iPrecio implantable pump.

Click to watch the webinar recording. To view the presentation full screen simply click the square icon located in the bottom-right corner of the video-viewer.

To download PDF copies of the presentations, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.

Additional References:

Discovering and Developing Molecules with Optimal Drug-Like Properties 
Editors: Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. Prisinzano
ISBN: 978-1-4939-1398-5 (Print) 978-1-4939-1399-2 (Online) 27 Sep 2014  

Discovery Formulations: Approaches and Practices in Early Preclinical Development
Shobha N. Bhattachar, David M. Bender, Stephanie A. Sweetana, James A. Wesley

Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 49-94 Chapter 2, 27 Sep 2014

Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
Roy J. Haskell, Kimberly A. Foster, Ching Kim Tye, Michael Morgen

Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 95-140 Chapter 3, 27 Sep 2014

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research
Tove Tuntland, Brian Ethell, Takatoshi Kosaka, Francesca Blasco, Richard Xu Zang, Monish Jain, Ty Gould, Keith Hoffmaster.

Front. Pharmacol., 28 July 2014

Optimising in vivo pharmacology studies—Practical PKPD considerations
Johan Gabrielsson, A. Richard Green, Piet H. Van der Graaf

Journal of Pharmagological and Toxicological Methods, Volume 61, Issue 2, March-April 2010, pp 146-156.

Syracuse University Magazine Article on Dr Robert Doyle’s Research: 

Primetech

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