Studying Flow Mediated Responses in Isolated Vasculature

Studying Flow Mediated Responses in Isolated Vasculature

Gain useful insights on how to examine flow-induced dilation in isolated blood vessels using pressure myography from a recognized leader in the field, Dr. Éric Thorin. 

The physiological significance and effects of flow on controlling and coordinating vascular function are well-appreciated.  However, flow-mediated regulation of vascular function is a complex and difficult mechanism to study experimentally. Care must be taken to select appropriate instrumentation to allow for precise control of intravascular pressure and intraluminal flow, while minimizing artifacts introduced by the small size of glass cannulae. With proper simultaneous control of intravascular pressure and intraluminal flow, the researcher will be able to explore such responses as flow-mediated dilation, flow-induced constriction and other physiological responses that depend upon shear stress in the vasculature.

During this webinar Dr. Éric Thorin, a leading expert in the effects of shear stress in the vasculature, explains key concepts in setting up a system for the purpose of examining flow-mediated responses in isolated blood vessels.  The webinar sponsor, Living Systems Instrumentationhas been supplying tools for in vitro studies of cardiovascular function for over 20 years.  Viewers will gain an understanding of how to setup and utilize a pressure arteriograph capable of simultaneous control of intravascular pressure and intraluminal flow.

Click to watch the webinar recording. To view the presentation full screen simply click the square icon located in the bottom-right corner of the video-viewer.

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Presenter:

Dr Éric Thorin
Professor,
Université de Montréal
Associate Director,
Research Centre at
The Montreal Heart Institute

Dr. Éric Thorin has a long-standing interest in the study and mechanisms of ageing related to the vascular endothelium. His laboratory has developed several approaches to investigate the functional consequences of ageing combined with risk factors for cardiovascular diseases (CVD) on the evolution of a reversible endothelial dysfunction to an irreversible vascular disease. His main areas of research include the study of the cerebrovascular and peripheral vascular dysfunction in the mouse model of human dyslipidemia and atherosclerosis, the molecular mechanisms leading to endothelial cell senescence and the impact of risk factors for CVD in patients with obesity, diabetes and coronary artery disease.

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