A Breath of Not-So-Fresh Air: the Combined Effects of Air and Noise Pollution
While air and noise pollution have been well documented independently, their combined effects are insufficiently discussed, until recently. In this blog post, we discuss a recent publication from Kuntic et al. on the combined and individual effects of these pollutants in mice.
Talking Real Science with Martin Young
This episode of Share Science features Dr. Martin Young, a professor of medicine at the University of Alabama at Birmingham. In this interview he shares his journey into cardiac metabolism and chronobiology as well as some notable mentors that helped him along the way.
Cancer Immunotherapy: Viruses, Vaccines, and other Immuno-Oncology Treatments
In this blog post, current cancer immunotherapy treatments are discussed, as well as some future directions for this rapidly developing field.
Celebrating Black Scientists: 5 Scientific Stories from the Past
In honor of Black History Month, this blog discusses 5 scientific stories from some historic Black and African-American scientists, researchers, and medical professionals.
Industry Insights with Crown Bioscience: Analyzing the Suppressive TME with In Vitro Based Assays
This episode of Industry Insights features Nataliia Beztsinna, PhD, and Marten Hornsveld, PhD, from Crown Bioscience as they describe how reconstituted TME and patient-derived ex vivo tissue assays can best be used within the drug development pipeline.
Protocol Preview: Long-read sequencing, Nature’s Method of the Year
Nature Methods declared "Long-Read Sequencing" their Method of the Year for 2022, but what exactly makes this technique worthy of such a title?
Talking Real Science with Yelena Akelina
This episode of Share Science features Yelena Akelina, DVM, MS, a Research Scientist and a Co-Director/Instructor in Clinical Microsurgery at the Microsurgery Research and Training lab at the Department of Orthopaedic Surgery, Columbia University.
The Blues & the Browns: Links between Depression and Gut Microbiota
Recently, Radjabzadeh et al., identified 13 genera of gut microbiota that have been implicated with symptoms of depression.
Brain-Derived Tau in Blood: the Future of Alzheimer’s Disease Diagnosis?
Recently published in Brain, Gonzalez-Ortiz et al. report the design and development of a novel blood-based biomarker specific to brain-derived tau. In this blog post, we dive into the advantages of their novel immunoassay over those that are commercially available, as well as its future implications for Alzheimer’s disease diagnosis.
Meet Rajesh Chaudhary, Cardiovascular Transplant Researcher and Rodent Microvascular Surgery Scholarship Recipient
Rajesh Chaudhary, PhD, recently won a Kent Scientific scholarship for the Comprehensive Training Program for Rodent Microvascular Surgery at Columbia University! We interviewed Rajesh to learn why he applied to this scholarship and what he skills he gained from this course.
Meet Saran Lotfollahzadeh, Vascular Surgeon and Rodent Microvascular Surgery Scholarship Recipient
Saran Lotfollahzadeh, MD, recently won a Kent Scientific scholarship for the Comprehensive Training Program for Rodent Microvascular Surgery at Columbia University! We sat down with Saran to learn why she applied to this scholarship, what skills she gained from the course, and more.
Protocol Preview: In Vivo Gene Therapy Using Peptide-Based Delivery
Although gene therapy has been in discussion for decades, its translation to clinical practice has been a slow and challenging process. As a solution to this translational challenge, Allen et al. have proposed a peptide-based delivery method of Cre recombinase for in vivo gene therapy, which we review in this blog post.
Industry Insights with Crown Bioscience: Targeting T Cells Within the Cancer-Immunity Cycle
In this episode of Industry Insights, Saskia De Man, PhD, Marrit Putker, PhD, and Pirouz Daftarian, PhD, from Crown Bioscience discuss assays and methods for evaluating T cell therapeutics, including organoids, co-cultures, and high content imaging.
Novel Targets for Alzheimer’s Disease Treatment: Medin and PLD3
Given that Alzheimer's disease is multifactorial and heterogenous, drug development progress is more likely to occur if multiple pathways are considered. Two recent Nature publications have potentially identified medin and PLD3 as new targets for Alzheimer’s disease treatment, which we summarize in this mini-review.
Meet Alicia Carrillo-Sepulveda, Vascular Physiologist and Rodent Microvascular Surgery Scholarship Recipient
Alicia Carrillo-Sepulveda, PhD, recently won a Kent Scientific scholarship for the Comprehensive Training Program for Rodent Microvascular Surgery at Columbia University! We sat down with Alicia to learn why she applied to this scholarship, what skills she gained from the course, and more.
A Novel Ingestible Biosensor for Intestinal Metabolite Monitoring
De la Paz et al. have developed an ingestible, self-powered, and wireless biosensing capsule that can hopefully be used for the noninvasive diagnosis of gastrointestinal disorders in the future. Recently published in Nature Communications, the authors demonstrated how its real-time performance in a porcine model, which we summarize in this post.
Particulate Matter from Firearms: Lung Toxicity and Respiratory Effects
While health and safety precautions are rightly focused on preventing shooting-related injury and death at firing ranges, heavy metal exposure also poses substantial health risks. Kim et al. recently modeled the acute health effects of particulate matter inhalation from firearm smoke in mice, which we review in this post.
Protocol Preview: a Ferret Model of Respiratory Inflammation
While rodents have long been used to model many human diseases, their anatomical, physiological, and immunological differences from humans cannot be ignored when modeling respiratory inflammation. Recently, Khoury et al. demonstrated how ferrets can be used to model inflammatory respiratory disease and injury, which we review in this blog post.
Are They Born This Way? Beat Synchronization in Rats in Response to Lady Gaga, Mozart, and More
Recently, Ito et al. sought to understand beat synchronization in rats and how it compares to humans, which has not been reported to date. In this blog post, we review their findings and how they contribute to our understanding of cross-species beat synchronization.
Orphan Receptor GPR55: A New Therapeutic Target for Atherosclerosis?
Since the role of GPR55 in adaptive B cell response regulation has not yet been reported in the context of atherosclerosis, Guillamat-Prats et al. have investigated how GPR55 in B cells affects atherosclerosis development. In this blog post, we highlight the main findings from this study, which was published this month in Nature Cardiovascular Research.
Mitochondrial Adaptations and Homeostasis: Student Research from the MHRC
The Muscle Health Research Centre (MHRC) is one of Canada's leading innovators in muscle physiology research. In this blog post, we finish our series of interviews with student researchers at the MHRC and learn more about their research objectives, findings, and goals.
Is DNA Vaccination the Future of Type 1 Diabetes Prevention and Management?
Given the fact that type 1 diabetes can vary considerably between individuals, a precision medicine-based therapeutic approach could revolutionize clinical care. Earlier this year, Postigo-Fernandez et al. evaluated a precision medicine approach to DNA vaccination in a mouse model of type 1 diabetes, which we review in this blog post.
Industry Insights with Crown Bioscience: In Vitro Technologies for Studying the Cancer-Immunity Cycle
In this episode of Industry Insights, Rajendra Kumari, PhD, and Gera Goverse, PhD, from Crown Bioscience answer questions about in vivo, in vitro, and ex vivo technologies and methods that can be used for immuno-oncology research along each step of the cancer-immunity cycle.
Sugar, Spice, and a Troubling Vice: Cardiovascular and Cancer Risk with Artificial Sweeteners
Artificial sweeteners appear to be the perfect solution to many of the health problems associated with high sugar consumption, but two recent publications may change the public's opinion on these sugar substitutes.
Industry Insights with Chris Rand from Aurora Scientific
This episode of Share Science features Chris Rand, MSc, sales and marketing manager at Aurora Scientific. In this interview, Chris shares Aurora Scientific’s history, their journey within the preclinical research world, and their advance into the neuroscience space.
