Preclinical Animal Models of IBD, GVHD, and Pulmonary Disease
Join BioModels’ Scientists, Andrew Borkowski, PhD and Nicole Smith, PhD, as they discuss a selection of key preclinical models of inflammatory disease, including models of Inflammatory Bowel Disease (IBD)/colitis, Graft vs Host Disease (GvHD), and pulmonary disease, focusing on the utility of clinically relevant endpoints that create highly translational models of human disease.
Assessing Antigen-Specific T Cell Functionality With Dendritic Cell/CD8⁺ T Cell Co-Culture
On December 12, 2023, STEMCELL Technologies' Dr. Catherine Ewen described, in detail, how to set up DC (dendritic cell) and CD8ᐩ T cell co-culture experiments that generate antigen-specific CD8ᐩ T cells, and how to assess CD8ᐩ T cell proliferation, functionality, and killing activity. In this Q&A report, you can read her answers to questions asked by the audience. Answers have been edited for length and/or clarity.
#ExpertAnswers: Catherine Ewen on Setting Up DC and CD8⁺ T Cell Co-culture Experiments
Dr. Catherine Ewen from STEMCELL Technologies answers questions from a recent webinar where she describes how to set up DC and CD8⁺ T cell co-culture experiments and assess T cell proliferation and activity.
#ExpertAnswers: Lorcan Sherry and Aditya Pratapa on Analyzing Multiplex Immunofluorescence Images
Dr. Lorcan Sherry and Dr. Aditya Pratapa answer questions from a recent webinar where they present a novel workflow for analyzing multiplex immunofluorescence images.
#ExpertAnswers: Conor McCartin on Phage Display Technologies
Dr. Conor McCartin from ProteoGenix answers questions about the utilization of phage display in the development of human antibodies.
#ExpertAnswers: Sarah Klein on SignalStar Multiplex IHC
Dr. Sarah Klein from Cell Signaling Technology answers questions from a recent webinar about accelerating spatial biology discoveries using SignalStar™ Multiplex IHC panels.
#ExpertAnswers: Matt Silva on Cryo-Fluorescence Tomography for Immunotherapy Research
Matthew Silva, PhD, CEO of EMIT Imaging, answers questions from a recent webinar where he highlights the role of cryo-fluorescence tomography in advancing the field of immunotherapy research.
#ExpertAnswers: Jack Vanden Heuvel on Using Cell-Based Bioassays and Effect-Based Methods for Water Quality Assessment
Dr. Jack Vanden Heuvel answers questions from a recent webinar on the use of cell-based bioassays and effect-based methods for water quality assessment.
#ExpertAnswers: Victor Arrieta on Anti-PD-1 Immunotherapy for Recurrent Glioblastoma
Dr. Víctor Andrés Arrieta explores how p-ERK activation links to better survival in rGBM patients treated with anti-PD-1 immunotherapy.
#ExpertAnswers: Arutha Kulasinghe on Single-Cell Spatial Phenotyping for Biomarker Discovery
Dr. Arutha Kulasinghe discusses application of single-cell spatial phenotyping for characterizing the tumor microenvironment.
Overcome the Multiple Challenges of Neutralizing Antibodies in Cancer Therapy Using Innovative Phage Display Technologies
Conor McCartin, PhD, answers questions about the benefits, applications, and process of using innovative phage display technology for cancer therapy and monoclonal antibody development.
A Ready-to-Analyze High-Plex Spatial Signature Development Workflow for Cancer Immunotherapy
In this webinar, Aditya Pratapa and Lorcan Sherry present a new workflow for analyzing multiplex immunoflurescence images.
Assessing Antigen-Specific T-Cell Functionality with Dendritic Cell/CD8⁺ T Cell Co-culture
In this webinar, learn how to set up DC and CD8⁺ T cell co-culture experiments and assess T cell proliferation and killing activity.
Exploring Predictive Biomarkers and ERK1/2 Phosphorylation: A New Horizon in Forecasting Survival and Response to Immune Checkpoint Blockade in Glioblastoma Treatment
Víctor Andrés Arrieta, MD, PhD presents glioblastoma research, covering multiplex immunofluorescence, predictive biomarkers, and ERK1/2 phosphorylation.
Overcome the Multiple Challenges of Neutralizing Antibodies in Cancer Therapy Using Innovative Phage Display Technologies
In this webinar, Dr. Conor McCartin discusses how phage display can be used for human antibody development.
Unlocking Spatial Insights: Accelerate Discoveries 70% Faster with SignalStar™ Multiplex IHC
Join us to learn how to accelerate spatial biology discoveries by 70% with optimized, ready-to-go panels using SignalStar™ Multiplex IHC.
Advancing Water Quality Monitoring: How to Easily Integrate Advanced Bioanalytical Techniques for Comprehensive Insights
Dr. Jack Vanden Heuvel discusses how integrating cell-based bioassays and effect-based trigger values enhances water quality assessment beyond traditional methods.
Revolutionizing Immunotherapy Research with 3D, Multiplexed Cryo-fluorescence Tomography
Dr. Matt Silva showcases the power of cryo-fluorescence tomography (CFT) in advancing immunotherapy research.
Exploring Predictive Biomarkers and ERK1/2 Phosphorylation: A New Horizon in Forecasting Survival and Response to Immune Checkpoint Blockade in Glioblastoma Treatment
In this webinar, Victor Arrieta highlights the link between p-ERK activation and improved survival in rGBM patients using anti-PD-1 immunotherapy.
Spatial Phenotyping: A Revolutionary Approach to Biomarker Discovery for Cancer Immunotherapy
Dr. Arutha Kulasinghe discusses the potential of single-cell spatial phenotyping in biomarker analysis and how it can be used to characterize tumor microenvironments.
Tick Tock: The Growing Risk of Lyme Disease and Efforts to Develop a Vaccine
In this blog we discuss Lyme disease, including reasons for increased prevalence, causes and symptoms, and vaccine developments.
Real-time IntraVital Microscopy (IVM): In Vivo Live Cell Imaging in Immunology and Neuroscience with Live Imaging Demo
Selina Soyeon Ahn, PhD introduces IVIM Technology’s All-in-One real-time intravital confocal and two-photon microscopy system and its application to immunology and neuroscience research.
#ExpertAnswers: Nataliia Beztsinna and Marten Hornsveld on Pre-Clinical Immuno-Oncology
Nataliia Beztsinna and Marten Hornsveld describe how the tumor microenvironment modulates clinical responses and how patient-derived ex vivo and engineered in vitro models can be used for pre-clinical immuno-oncology testing.
What’s Next in Preclinical Cancer Immunotherapy Research?
Experts answers questions about key topics in the field of cancer immunotherapy, including new and emerging methods and future directions.