In this episode of Expert Answers join Dr. Tim West and Matt Borkowski for a discussion on how to properly isolate and prepare, and assess muscle performance and contractile function in single muscle fibers.
Dr. Charlotte Peterson and Dr. Jack Guralnik will discuss the challenges of sarcopenia. They will define the disease and provide an in depth overview of the underlying mechanisms of pathology. They will then share some potential therapeutic interventions and disease outcomes for patients.
Abstract coming soon! The Bodine laboratory is interested in identifying the mechanisms responsible for muscle atrophy and determining strategies for preventing atrophy or accelerating recovery following a period of muscle loss.
Register for the 36th Annual Academy of Surgical Research Virtual Meeting to join surgical research professionals around the world in a two-day exploration of surgical techniques, research applications, technology advancements and industry trends.
Experts present key considerations in the design of rigorous preclinical studies in rodent models of muscular dystrophy, including animal model selection, assays and endpoints, and how your results can inform translation to the clinic.
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.
Aaron Stupica and Keshari Thakali discuss techniques tissue bath myography and present a unique case study looking at the effect of maternal obesity on offspring perivascular adipose tissue and vascular function.
Part 1 of a webinar series designed to survey biomechanics; starting with its core components of kinematics, kinetics, and neuromuscular activation and progressing to their application within research and industry.