Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Christopher Perry, PhD discusses how his laboratory aims to discover mechanisms by which metabolic dysfunction causes muscle weakness and apply these findings to develop new therapies for muscle disorders. Homira Osman, PhD provides a particular focus on leveraging scientific findings for practice and policy and linking trainees with patient communities.
While the immune response to a single cardiac event has been well researched, few have reported on whether an adaptive immunity is observed after repeated cardiac injury. Here, we discuss a recent publication from Tiwary et al., in which they investigate the cytoprotective response after multiple cardiomyopathic injuries.