Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
In this episode of Expert Answers, Dr. Jack Guralnik and Dr. Charlotte Peterson answer questions about sarcopenia, the physiological mechanisms underlying the disease, and the current avenues of treatment and assessment.
Dr. Charlotte Peterson and Dr. Jack Guralnik will discuss the challenges of sarcopenia. They will define the disease and provide an in depth overview of the underlying mechanisms of pathology. They will then share some potential therapeutic interventions and disease outcomes for patients.
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
In this episode of Expert Answers join Dr. Tim West and Matt Borkowski for a discussion on how to properly isolate and prepare, and assess muscle performance and contractile function in single muscle fibers.