protein aggregation Archives

#ExpertAnswers: Luke Holloway on Protein Characterization

Luke Holloway reviews light scattering-based methods for protein characterization and explains their utility in understanding aggregation propensity of monoclonal antibodies.

Using Chemical Denaturants and Light Scattering to Determine Aggregation Propensity of Biopharmaceuticals

liamisc2023-03-27T15:58:49-04:00Analytical Sciences, Drug Discovery & Development, Pharmacology|

Dr. Luke Holloway reviews light scattering-based methods for protein characterization and explains their utility, when combined with partially denaturing buffers, in understanding aggregation propensity of monoclonal antibodies.

Detection of Protein Aggregation During Biopharmaceutical Development: The Role of Orthogonal Techniques

liamisc2023-03-27T15:17:32-04:00Drug Discovery & Development, Microscopy, Pharmacology|

Dr. Danny Chou discusses the opportunities and challenges in orthogonal particle analysis, and how flow imaging microscopy and light obscuration can be used for formulation development and quality control.