The goal of this study is to understand how autophagy and other proteolytic processes are regulated in skeletal muscle, specifically looking at the Atg1 homologs, ULK1 and ULK2, as they play distinct roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation, and autophagy. These catabolic processes are often dysregulated in metabolic and skeletal muscle disorders such as type II diabetes, sarcopenia, and obesity. Understanding the molecular workings of these processes will help to maintain proper metabolism, muscle quality, and overall health thereby attenuating the negative side effects associated with these diseases.
To download a PDF copy of the presentation, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.
Jordan Fuqua, MSc PhD Candidate Lira Lab University of Iowa
Jordan Fuqua is a PhD candidate at the University of Iowa. His research focuses specifically on the regulation of autophagy and protein turnover in skeletal muscle and the impact it has on metabolic and muscle diseases. In addition to research he loves to teach physiology and help students understand the intricate and awesome details of how the human body operates.
The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
Matt Borkowski of Aurora Scientific discusses the latest software update for their Dynamic Muscle Control and Analysis Software, DMC LabBook.
Experts discuss the A-to-Z of assessing muscle performance and contractile function in single muscle fibers.
Experts discuss how to characterize the mechanical properties of tendon using a novel dual-mode lever system.
Learn how to characterize complete muscle function by combining lengthening, shortening and isotonic contraction tests with traditional isometric twitch and tetanus measurements.
An essential webinar for all muscle researchers interested in methodology, best-practices, and techniques for in-vivo, in-vitro, and in-situ muscle experimentation.