ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle

PhD Candidate
Lira Lab
University of Iowa

The goal of this study is to understand how autophagy and other proteolytic processes are regulated in skeletal muscle, specifically looking at the Atg1 homologs, ULK1 and ULK2, as they play distinct roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation, and autophagy. These catabolic processes are often dysregulated in metabolic and skeletal muscle disorders such as type II diabetes, sarcopenia, and obesity. Understanding the molecular workings of these processes will help to maintain proper metabolism, muscle quality, and overall health thereby attenuating the negative side effects associated with these diseases.

To download a PDF copy of the presentation, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.

This Virtual Poster has been made available to the scientific community by Aurora Scientific, Inc.

Aurora Scientific, Inc.

Aurora Scientific supports the scientific community in its goal of research and discovery by providing precision instrumentation of the highest quality design, construction and functionality for Muscle Physiology, Material Science and Neuroscience applications.

Aurora Scientific, Inc.

Additional Content From Aurora Scientific, Inc.

Cut and Paste of Myosin Binding Protein-C in Striated Muscles

Cut and Paste of Myosin Binding Protein-C in Striated Muscles

Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Christopher Perry, PhD discusses how his laboratory aims to discover mechanisms by which metabolic dysfunction causes muscle weakness and apply these findings to develop new therapies for muscle disorders. Homira Osman, PhD provides a particular focus on leveraging scientific findings for practice and policy and linking trainees with patient communities.

Related Content