The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear


Christopher Mendias Lab
Hospital for Special Surgery

Alex Piacentini graduated from his undergrad at Binghamton University in 2016 with a BS in Biological Sciences. He then went to Tufts University for a Master’s in Conservation Medicine. This research focused on wildlife conservation and bringing multiple scientific specialties together to encourage collaboration across disciplines. Alex is very interested in the connections within biological systems and using them in novel ways to solve complex, multifactorial problems.

Analyzing whether MRL mouse strain has any enhanced healing ability after injury in skeletal muscle. This strain has been touted as a “superhealer” although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.

To download a PDF copy of the presentation, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.

This Virtual Poster has been made available to the scientific community by Aurora Scientific, Inc.

Aurora Scientific, Inc.

Aurora Scientific supports the scientific community in its goal of research and discovery by providing precision instrumentation of the highest quality design, construction and functionality for Muscle Physiology, Material Science and Neuroscience applications.

Aurora Scientific, Inc.

Additional Content From Aurora Scientific, Inc.

Setup and Use of the 3-in-1 Whole Animal System

Setup and Use of the 3-in-1 Whole Animal System

The Aurora Scientific team will perform a live virtual demonstration of their 3-in-1 Whole Animal System, using a methodology focused overview of the 3 main experimental techniques for assessing contractility of whole muscle in murine models.
Cut and Paste of Myosin Binding Protein-C in Striated Muscles

Cut and Paste of Myosin Binding Protein-C in Striated Muscles

Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Christopher Perry, PhD discusses how his laboratory aims to discover mechanisms by which metabolic dysfunction causes muscle weakness and apply these findings to develop new therapies for muscle disorders. Homira Osman, PhD provides a particular focus on leveraging scientific findings for practice and policy and linking trainees with patient communities.

Related Content