Elizabeth Redente, PhD
Associate Professor of Paediatrics
National Jewish Health
Elizabeth Redente is an Associate Professor of Paediatrics at National Jewish Heath in Denver, CO. Her research focuses on the development and resolution of pulmonary fibrosis using animal models. The use of microCT imaging modalities has been an important tool for her research program and the longitudinal study of animals during therapeutic treatment. She is currently funded by the NIH to study silica-induced pulmonary fibrosis and pre-clinical interventions.
Her career interests are focused on the interactions between TNF-α, macrophages and myofibroblasts and their role in the resolution of established pulmonary fibrosis with the goal to investigate the mechanisms by which TNF-α resolves fibrosis as the basis for the translational application of this work as a potential therapeutic. She plans to elucidate the mechanisms by which TNF-α is reducing the pro-fibrotic phenotype of macrophages and myofibroblasts and via the creation of an anti-fibrotic lung microenvironment. The importance of understanding how macrophages are shaping the lung environment during disease and how these interactions can be modulated to influence disease resolution is an important research direction that can be applied to many diseases including fibrosis and cancer. It is Dr. Redente’s goal that her basic science findings conducted in mouse models be translatable to human disease and into potential therapeutic treatments.