Dr. Éric Thorin has a long-standing interest in the study and mechanisms of ageing related to the vascular endothelium. His laboratory has developed several approaches to investigate the functional consequences of ageing combined with risk factors for cardiovascular diseases (CVD) on the evolution of a reversible endothelial dysfunction to an irreversible vascular disease. His main areas of research include the study of the cerebrovascular and peripheral vascular dysfunction in the mouse model of human dyslipidemia and atherosclerosis, the molecular mechanisms leading to endothelial cell senescence and the impact of risk factors for CVD in patients with obesity, diabetes and coronary artery disease.