Trained as a physician scientist, Dr. Yan has over 30 years of research experience with private and federal funding. He has established a rigorous research program and developed unique genetic and exercise models with >110 publications in high-impact journals of including Nature Communications, Diabetes, Free Radical Biology & Medicine, and Circulation: Heart Failure. His laboratory employs state-of-the-art molecular genetics and imaging technologies in a variety of animal models to elucidate the underlying molecular and signaling mechanisms of exercise training-induced adaptations and their impacts on health and disease. His long-term goal is to unveil the underlying mechanisms of exercise training and its impact on health and diseases.