ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies

ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies

VIRTUAL POSTER

Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.

ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle

ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle

VIRTUAL POSTER

Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.

The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear

The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear

VIRTUAL POSTER

The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.

Turn Away from Traditional Tethering and Towards a Better Method for Data Collection

Turn Away from Traditional Tethering and Towards a Better Method for Data Collection

ON DEMAND

Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.

Place Cell Mapping and Stress Monitoring in Head-Fixed Mice Navigating an Air-Lifted Homecage

Place Cell Mapping and Stress Monitoring in Head-Fixed Mice Navigating an Air-Lifted Homecage

ON DEMAND

Scientists present data on 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed awake behaving mice.

Harnessing EEG Methods to Improve Basic and Translational Research for CNS Disorders

Harnessing EEG Methods to Improve Basic and Translational Research for CNS Disorders

ON DEMAND

Dr. Robert Gould and Mike Girand discuss methods and applications for the use of EEG as a highly translational biomarker for sleep, substance use disorder and CNS disorders.