Overcoming Critical Issues in Glioblastoma Multiforme (GBM) Therapeutic Development
This article, originally published on Scientist.com, reviews the current standard of care for glioblastoma multiforme (GBM), challenges in developing accurate preclinical GBM models and effective therapies, and the future of GBM drug discovery.
Intestinal Toxicity Assessment with Patient-Derived Organoids
Dr. Martin Stahl describes the use of patient-derived intestinal organoids to assess the toxicity of potential therapeutic compounds and study barrier function in a human-specific model system.
Combination Therapy for Cancer Treatment
The combination of anti-cancer drugs, or combination therapy, has been hailed as a “cornerstone of cancer therapy” since it targets key pathways synergistically, thereby enhancing efficacy compared to monotherapies. This blog takes a look at a recent publication in Nature, which reported the effects of 2025 pairwise drug combinations in breast, colon, and pancreatic cell lines.
#ExpertAnswers: Peter Ansell and Marian Navratil on Gene Expression Profiling
Peter Ansell and Dr. Marian Navratil discuss the use of novel RNA-based gene expression profiling technologies for clinical and preclinical oncology research.
Discovering a Novel Therapy for Urinary Tract Infections
Originally published on Scientist.com, this article provides an overview of antimicrobial therapies, antimicrobial resistance, and advantages of in silico methods for drug discovery.
Inhalable COVID-19 Vaccines: Recent Findings and Breakthroughs
Given that SARS-CoV-2 is primarily transmitted through respiratory droplets, with respiratory mucosa being the main viral entry route, is intramuscular administration the most effective vaccine delivery method to fight COVID-19? In this blog post, we have reviewed one recent study that reported the design and preclinical testing of an inhalable, exosome-based COVID-19 vaccine.
Cell Painting: The Colorful Future of Drug Discovery
A panel Q&A originally published on Scientist.com that introduces cell painting and highlights its value in preclinical and early drug discovery programs.
A Novel, All-Human Hepatic Triculture System
Join Edward LeCluyse and Paul Gallant as they discuss LifeNet Health LifeSciences' novel, all-human hepatic triculture system and discuss how it addresses the need for a convenient and human-relevant long-term hepatic culture.
#ExpertAnswers: Edward LeCluyse and Paul Gallant on a Novel Hepatic Triculture System
Edward LeCluyse and Paul Gallant discuss their novel all-human hepatic triculture system including its benefits and applications.
Alzheimer’s Disease: Recent Research & Therapeutic Advances
A review of Alzheimer's disease pathology, conventional treatments and their limitations, as well as emerging and potential therapies including monoclonal antibodies, metabolic therapies, and stem cell therapies.
Integration of the HTG Transcriptome Panel into Preclinical and Clinical Programs to Drive Precision Medicine Research
Dr. Peter Ansell discusses the use of novel RNA-based gene expression profiling methods for clinical and preclinical oncology research.
A Novel, All-Human Hepatic Triculture System
Join Edward LeCluyse and Paul Gallant as they offer insight into a novel, all-human hepatic triculture and how this unique system addresses the need for a convenient and human-relevant long-term hepatic culture.
#ExpertAnswers: Bin Xie on Drug Development for Immuno-Oncology
Bin Xie discusses the current immuno-oncology drug development landscape, different humanized mouse models available for drug testing, and the investigation of potential mechanisms via imaging mass cytometry.
#ExpertAnswers: Anuj Kalsy and Robert Snyder On The Variant-Rich Biobank
Anuj Kalsy and Robert Snyder showcase Precision for Medicine's variant-rich biobank, including discussion on biospecimen types, applications, screening methods, and support for companion diagnostic development.
Recent Advances in Anti-Obesity Pharmacological Research
A review of current obesity treatments and their limitations, the need for animal models in obesity research, and emerging anti-obesity medications including incretin-based therapies, mitochondrial uncouplers, and various phytochemicals.
The Variant-Rich Biobank: An Insider’s Look
Experts provide a showcase of Precision for Medicine's variant-rich biobank. including discussion on biospecimen types, applications, screening methods, and support for companion diagnostic development.
Current and Novel Immuno-Oncology Drug Evaluation Methods via Humanized Mouse Models
Dr. Bin Xie discusses the current immuno-oncology drug development landscape, different humanized mouse models available for drug testing, and the investigation of potential mechanisms via imaging mass cytometry.
Research Technology & Innovation Summits
The 2022 InsideScientific Research Technology & Innovation Summits focus on specific research and therapeutic areas, reviewing how novel technologies and innovative services are advancing discovery in each particular field.
Respiration in Anesthetized Mice: Evidence-Based Recommendations for Improved Monitoring & Supportive Care
Dr. James Marx answers questions from his recent webinar on improving the care and use of mice in biomedical research, with a focus on the effects of anesthetics on respiration.
Essential Bruker NMR Trainings 2022
Join Bruker experts for 1-hour every other week online for this essential training program designed for NMR Scientists.
Cutting Edge Conversations: Biomarkers – Challenges and Opportunities
The 5th and final episode in the Cutting Edge Conversation series for 2021 features Dr. Morad Nakhleh, Natalie Smith, and Dr. Bhavika Patel as they discuss industry challenges and innovations surrounding biomarkers in life science research and precision medicine
Milestones and Recent Advances in HIV Research
In honor of World AIDS Day, InsideScientific has set out to provide information on the historical significance of HIV and AIDS, recent advances in anti-HIV therapy, and the impact that COVID-19 has had on HIV testing, diagnosis and treatment around the world.
Cerebral Open Flow Microperfusion (cOFM) for in vivo Cerebral Fluid Sampling – Comparison of cOFM and Microdialysis
Dr. Joanna Hummer and Dr. Florie Le Prieult share insights into cOFM's use and utility in the broader neuroscience field and specifically for the development of drugs for neurodegenerative diseases.
Infrared Spectroscopy for Biological and Biomedical Applications
Experts discuss the uses of infrared spectroscopy for biological and biomedical applications.
