Considerations for Rigorous Pre-clinical Studies in Murine Muscular Dystrophy

Considerations for Rigorous Pre-clinical Studies in Murine Muscular Dystrophy

WED, AUGUST 19, 2020

Experts present key considerations in the design of rigorous preclinical studies in rodent models of muscular dystrophy, including animal model selection, assays and endpoints, and how your results can inform translation to the clinic.

Cardiac PV Loop Data Analysis: Tips & Tricks

Cardiac PV Loop Data Analysis: Tips & Tricks

ON DEMAND

Dr. DeWayne Townsend and Dr. Adam Goodwill discuss the fundamentals of pressure-volume loop analysis as a means to study cardiac function.

ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies

ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies

VIRTUAL POSTER

Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.

ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle

ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle

VIRTUAL POSTER

Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.

The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear

The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear

VIRTUAL POSTER

The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.