Optogenetics Telemetry – Shining a Light on Long-Term Optogenetic Stimulation with Telemetry
Dr. Sarah-Jane Guild provides an introduction to optogenetics, discusses the advantages of implantable optogenetics telemetry and reviews data collection using the Kaha Sciences Optogenetics system.
Improving Animal Modeling with 24/7 Home Cage Monitoring in Bioexclusion & Biocontainment Mouse Housing Systems
Experts discuss current biosafety requirements and what home cage monitoring can teach us in bioexclusion and biocontainment studies.
The Use of Home Cage Monitoring to Determine Whether Individual Male Mouse Activity Patterns Correlate With Nest Complexity
It is well established that nesting materials are an important inclusion for mouse cages. We wanted to determine whether there was a significant difference in mice activity when offered three different material choices and whether there was any correlation between activity in the cage and nest complexity.
#ExpertAnswers: Kaushikaram Subramanian & Volker Enzmann on the Optomotor Reflex
In this episode of Expert Answers, Drs. Subramanian & Enzmann share case studies and experimental data from various applications using a newly developed automated system to measure vision based on the optomotor reflex.
A New Frontier of Precision Medicine: Using PET for Image-Guided Neurointerventions
Experts discuss how PET/CT imaging can be used to enable image-guided neurointerventions and to study targeted delivery and clearance of therapeutic agents.
Cardiac PV Loop Data Analysis: Tips & Tricks
Dr. DeWayne Townsend and Dr. Adam Goodwill discuss the fundamentals of pressure-volume loop analysis as a means to study cardiac function.
#ExpertAnswers: Tonya Coulthard on the Capabilities of PET/CT Imaging
Tonya Coulthard discusses the features and benefits of SuperArgus PET/CT systems and reviews its unique capabilities.
SuperArgus PET/CT: Advanced Pre-Clinical Imaging for Small to Medium Animals
Tonya Coulthard discusses the SuperArgus PET/CT systems, reviewing both basic and unique imaging capabilities, including real-time imaging of awake animals as well as multiplexed PET imaging of standard and non-standard isotopes.
Odor delivery with the 220A Olfactometer from Aurora Scientific
Chris Rand discusses the updated 200A Olfactometer from Aurora Scientific. He walks through setting up the system before sharing best practices, all while demonstrating the integral functions of the system.
Measuring Visual Acuity and Contrast Sensitivity by Optomotor Reflex in Rodents
Experts discuss case studies and experimental data from various applications using a newly developed automated system to measure vision based on the optomotor reflex.
ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
RRSSC – Rodent Glucose Clamp Workshop
This workshop is essential for those looking to master the glucose clamp technique in awake and behaving mice and rats. These models allow for glucose clamping using instruments such as Instech's euglycemic clamp.
#ExpertAnswers: Robert Gould and Michael Girand on Utilizing EEG to Study Sleep, Substance Use and CNS Disorders
Robert Gould and Michael Girand discuss methods and applications for the use of EEG as a biomarker for sleep, substance use disorder and CNS disorders.
#ExpertAnswers: John Cirrito & Candace Rhode-Johnson on Micro-dialysis and Neuroscience
In this episode of Expert Answers, John Cirrito and Candace Rhode-Johnson discuss the use of a novel movement responsive rodent caging system.
The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear
The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle
Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.
Organize and Streamline Data Collection with DMC LabBook
Matt Borkowski of Aurora Scientific discusses the latest software update for their Dynamic Muscle Control and Analysis Software, DMC LabBook
#ExpertAnswers: Konrad Juczewski and Mary Ann Go on Place Cell Mapping and Stress Monitoring
Konrad Juczewski and Mary Ann Go discuss 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed, awake and behaving mice.
Turn Away from Traditional Tethering and Towards a Better Method for Data Collection
Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.
#ExpertAnswers: Ralph Lydic and Tally Largent-Milnes on the Opioid Epidemic
Ralph Lydic and Tally Largent-Milnes discuss physiological mechanisms behind the opioid epidemic and present their research on the effects of opioids on sleep and respiratory depression in preclinical mouse models.
Place Cell Mapping and Stress Monitoring in Head-Fixed Mice Navigating an Air-Lifted Homecage
Scientists present data on 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed awake behaving mice.
Harnessing EEG Methods to Improve Basic and Translational Research for CNS Disorders
Dr. Robert Gould and Mike Girand discuss methods and applications for the use of EEG as a highly translational biomarker for sleep, substance use disorder and CNS disorders.
#ExpertAnswers: Melanie White on Isolated Langendorff Heart Principles
Melanie White discusses basic isolated Langendorff heart principles, key experimental design considerations, core technology requirements and best practice tips to support consistency and validation of your research.
Understanding Physiological Mechanisms of Opioid Addiction: Advancements in CNS and Respiratory Endpoint Measurement
Experts discuss how opioids affect sleep and respiratory depression in preclinical mouse models.
#ExpertAnswers: Sarah Stuart, Jon Pacios-Filardo, Alexander Dityatev, Weilun Sun, and Norbert Hájos on Neurophysiology
Five experts from the University of Bristol, the German Center for Neurodegenerative Diseases, and the Hungarian Academy of Sciences answer questions from a webinar where they present methodology and research findings from neurophysiological studies in head-fixed, behaving mice.