20 Years of TRPV4 - Exploring Science, Discovery, and Future Directions

20 Years of TRPV4 – Exploring Science, Discovery, and Future Directions

Virtual Conference: June 8 – 11, 2021

TRPV4 was first published at the end of 2000 where it became a part of the TRP ion channel superfamily. As a polymodally-activated calcium-permeable, non-selective cation channel it is a family member in good standing to this day.

In the last two decades, we have witnessed fascinating discoveries which have moved us toward an improved understanding of TRPV4’s basic mechanism of action, its physiologic, pathophysiologic and etiopathogenic (mal-)function. 

The 20-year-birthday meeting to honor TRPV4 will be a welcome opportunity to celebrate this wide spectrum of topics, supported by deep and cutting-edge inquiry, and united by a focus on TRPV4 as a relevant molecular player. Therefore the aim of our meeting is to integrate the entire TRPV4 story as it has unfolded so far, so that all researchers can reassess their concepts and future exploratory directions. We also intend to clarify TRPV4-related areas of interest to new colleagues, teachers and communicators so that new concepts can be developed and the amazing TRPV4 story can be shared with a global audience.

This conference is recognized and officially supported by
The American Physiological Society

American Physiological Society

Words from the Program Chair

“To have a meeting to honor 20 years of TRPV4 guarantees to take us on an exciting excursion out of our own comfortable territory, and into other stimulating areas that will cover a wide spectrum of biomedically-relevant physiology.

The common denominator for all will be TRPV4. I am so excited about the roster of conference speakers who will present their stories and unique insights, making our meeting a global scientific event of the first rate. I am so looking forward to welcoming all of you in June 2021 – be there!”

Wolfgang Liedtke MD, PhD

Wolfgang Liedtke, MD, PhD

Registration

Agenda

Makoto Tominaga

Physiological Significance of TRPV4 in Glia Cells

Makoto Tominaga MD, PhD. Professor, Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki, Japan

Synthetic Mechanogenetic Gene Circuits

Farshid Guilak, PhD. Professor, Orthopaedic Surgery, Washington University in St. Louis

Preclinical Studies Using TRPV4 Antagonists to Treat Hydrocephalus

Bonnie Blazer-Yost, PhD. Professor, Biology Department Indiana University – Purdue University Indianapolis

A 20-year Journey Discovering the Physiology of TRPV4 in the Regulation of Endothelial Barrier Properties

Diego Alvarez MD, PhD. Professor and Chair, Physiology and Pharmacology, Sam Houston State University

Structural Insights into TRPV4 Function

Peng Yuan, PhD. Associate Professor, Cell Biology and Physiology, Washington University School of Medicine

TRPV4 Channel-Dependent Signaling Microdomains in the Vasculature

Swapnil Sonkusare, PhD. Assistant Professor, Physiology, University of Virginia

Function and Dysfunction of TRPV4 Channels in the Alveolar Epithelium

Alexander Dietrich, Prof. Dr. Principal Investigator, Experimental Pharmacology, Walther-Straub-Institute, LMU-Munich, Germany

Activation of TRPV4 on Dural Afferents Produces Headache Behavior in a Preclinical Rat Model

Greg Dussor, PhD. Associate Professor, Neuroscience, University of Texas at Dallas

Beyond Photons: TRPV4 as a Key Regulator of Mechanosensing and Signalling in the Healthy and Diseased Eye

David Krizaj, PhD. Professor, Ophthalmology & Visual Sciences, University of Utah

TRPV4 and Mechanosensory Signalling in Astrocytes

Alexander Gourine, PhD. Professor of Physiology, Neuroscience, Physiology and Pharmacology, University College London

Endothelial TRPV4 Channels Prevent Tumor Growth and Metastasis via Modulation of Tumor Angiogenesis and Vascular Integrity

Charles Thodeti, PhD. Associate Professor, Integrative Medical Sciences, Northeast Ohio Medical University

TRPV4 Temperature Sensitivity to Remote Control of Neurons

Ali Guler, PhD. Associate Professor, Biology, University of Virginia

Role and Mechanism of TRPV4-PI3Kgamma Interactions in Myofibroblast Differentiation and Pulmonary Fibrosis

Mitchell Olman, MD, MA, Professor of Molecular Medicine, Inflammation and Immunity, Lerner Research Institute- Cleveland Clinic

Mechanosensation in Macrophages Protects the Lung from Infection-Associated Lung Injury via TRPV4-Rac1-MAPK Axis

Rachel Scheraga, MD, Assistant Professor of Medicine, Respiratory Institute: Pulmonary and Critical Care Medicine, Cleveland Clinic

TRPV4 Activity in the Distal Nephron Controls Systemic K+ Homeostasis

Oleh Pochynyuk, PhD. Associate Professor, Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston

TRPV4 Inhibition, a Potential Strategy to Prevent Increased Water Diffusion and Blood-Retina Barrier Breakdown in the Diabetic Retina

Stéphanie Thébault, PhD. Permanent Researcher, Neurobiology of Development and Neurophysiology, UNAM

Epithelia-Sensory Neuron Crosstalk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine

Yong Chen, PhD. Assistant Professor, Neurology, Duke University Medical Center

Activation Modes by Different Agonists in TRP Channels

Tamara Rosenbaum, PhD. Professor, Cognitive Neuroscience, National Autonomous University of Mexico

Role of TRPV4 in Pancreatitis

Rodger Liddle, MD, Professor of Medicine, Medicine, Duke University

The Gut Brain Axis and Chronic Visceral Pain

Stuart Brierley, PhD. Professor, Visceral Pain Research Group, Flinders University

TRPV4 – a Key Regulator of Endothelial Barrier Function in the Lung

Wolfgang Kuebler, MD, Professor, Institute of Physiology, Charité – Universitätsmedizin Berlin

TRPV4 in Modulating Environmental Effects on NAFLD

Saurabh Chatterjee, PhD. Associate Professor, Departments of Environmental Health and Medicine, University of South Carolina

TRPV4 Channels in Neural Circuits Mediating Fluid Homeostasis

Charles Bourque, PhD. Professor, Neurology Neurosurgery, Research Institute McGill University Health Center

Oxidative Stress Mediates Thalidomide-Induced Pain by Targeting Peripheral TRPA1 and Central TRPV4

Francesco De Logu, PhD. Scientific Researcher & Romina Nassini, Professor, Health Sciences, University of Florence

The Role of TRPV4 in Lower Urinary Tract Pathways with Bladder Inflammation or Following Spinal Cord Injury

Margaret Vizzard, BA, PhD. Professor and Vice-Chair of Education, Neurological Sciences, Larner College of Medicine at The University of Vermont

Defining TRPV4 Expression and Function in the Gastrointestinal Tract

Daniel Poole, PhD. Research Fellow, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences

Interrogate Molecular Functions at the Organism Level

Li Ye, PhD. Assistant Professor, Neuroscience, The Scripps Research Institute

The Role of TRPV4 Ion Channels in Joint Pain

Hans-Georg Schaible, Prof. Dr. Director, Institute Physiology Neurophysiology, University Hospital Jena, Friedrich-Schiller University

Oxidative Stress Mediates Thalidomide-Induced Pain by Targeting Peripheral TRPA1 and Central TRPV4

Romina Nassini, PhD. Professor, & Francesco De Logu, PhD. Scientific Researcher, Health Sciences, University of Florence

Role of TRPV4 in Foreign Body Response to Biomaterials

Shaik Rahaman, PhD. Associate Professor, Nutrition and Food Science, University of Maryland

Mechanical Activation of TRPV4 in the Cell-Substrate Interface

Kate Poole, PhD. Associate Professor, Single Molecule Science, University of New South Wales

Epidermal TRPV4 Ion Channels Regulate UVB induced sunburn by Triggering Inflammasome Activation and ERK Signalling

Carlene D. Moore, PhD. Associate Professor, Neurology, Duke University Medical Center

Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium Tuberculosis Early and Late in Infection

Avinash Sonawane, PhD. Professor, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore)

Miguel Valverde

Mechanosensitive Ion Channels in Confined cell Migration

Miguel A. Valverde, PhD. Professor of Physiology, Experimental Sciences and Health, Universitat Pompeu Fabra

Defining Functional Crosstalk Between TRPV4 and Pro-Inflammatory GPCRs

Nicholas Veldhuis, PhD. Senior Research Fellow, Drug Discovery Biology, Monash University

Mechanisms Underlying Neurogenic TRPV4 Channelopathies

Charlotte Sumner, MD. Professor of Neurology and Neuroscience, Johns Hopkins University School of Medicine