An Improved Method for Studying Mouse Diaphragm Function
A detailed and ready-to-use protocol on the design and manufacturing of diaphragm clamps, and how to mount them to a muscle force measurement system.
Perception and Encoding of Temporally Patterned Odour Stimuli in Mice
Dr. Dasgupta explains his unique methodology and applications for analyzing the temporal structure of odour plumes.
The Use of Home Cage Monitoring to Determine Whether Individual Male Mouse Activity Patterns Correlate With Nest Complexity
It is well established that nesting materials are an important inclusion for mouse cages. We wanted to determine whether there was a significant difference in mice activity when offered three different material choices and whether there was any correlation between activity in the cage and nest complexity.
Locomotor Activity: refinement, reduction and replicability ‘round the clock in animal studies
A growing body of evidence suggests that Home Cage Monitoring studies are becoming key tools for in vivo animal research for three main reasons: reduction in animal distress thereby increasing welfare, minimization of biases (wanted and unwanted), and increased reproducibility of data.
ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear
The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle
Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.
