Preclinical Animal Models of IBD, GVHD, and Pulmonary Disease
Join BioModels’ Scientists, Andrew Borkowski, PhD and Nicole Smith, PhD, as they discuss a selection of key preclinical models of inflammatory disease, including models of Inflammatory Bowel Disease (IBD)/colitis, Graft vs Host Disease (GvHD), and pulmonary disease, focusing on the utility of clinically relevant endpoints that create highly translational models of human disease.
Next-Generation Safety Assessment Tools for Advancing In Vivo to In Vitro Translation
In this webinar, Dr. Louis Scott discusses the morph_ONE™ assay, a novel tool for in vitro safety assessment in drug development.
Turning Innovative Features Into Practical Benefits Within the Buxco Nose-Only Rodent Inhalation System
UV Shemesh discusses inhalation studies, including filters, aerosol, cleaning, and future research directions.
Turning Innovative Features Into Practical Benefits Within the Buxco Nose-Only Rodent Inhalation System
UV Shemesh presents Buxco's nose-only rodent inhalation system, highlighting how it can improve research efficiency and offer valuable insights in respiratory studies.
A Breath of Not-So-Fresh Air: the Combined Effects of Air and Noise Pollution
While air and noise pollution have been well documented independently, their combined effects are insufficiently discussed, until recently. In this blog post, we discuss a recent publication from Kuntic et al. on the combined and individual effects of these pollutants in mice.
Particulate Matter from Firearms: Lung Toxicity and Respiratory Effects
While health and safety precautions are rightly focused on preventing shooting-related injury and death at firing ranges, heavy metal exposure also poses substantial health risks. Kim et al. recently modeled the acute health effects of particulate matter inhalation from firearm smoke in mice, which we review in this post.
Protocol Preview: a Ferret Model of Respiratory Inflammation
While rodents have long been used to model many human diseases, their anatomical, physiological, and immunological differences from humans cannot be ignored when modeling respiratory inflammation. Recently, Khoury et al. demonstrated how ferrets can be used to model inflammatory respiratory disease and injury, which we review in this blog post.
#ExpertAnswers: Valeria Fumagalli and Nancy Kouassi on the Syrian golden hamster model of COVID-19
Valeria Fumagalli and Nancy Kouassi discuss the Syrian golden hamster model of COVID-19, and present a new inhalation exposure-based mouse model using aerosolized SARS-CoV-2.
Inhalable COVID-19 Vaccines: Recent Findings and Breakthroughs
Given that SARS-CoV-2 is primarily transmitted through respiratory droplets, with respiratory mucosa being the main viral entry route, is intramuscular administration the most effective vaccine delivery method to fight COVID-19? In this blog post, we have reviewed one recent study that reported the design and preclinical testing of an inhalable, exosome-based COVID-19 vaccine.
Novel Animal Models and Methods for Studying COVID-19: Golden Hamsters and Aerosolized SARS-CoV-2 Delivery
Experts present two novel animal models of COVID-19 and highlight recent research conducted using these models.
Visualizing the Intracellular Immune Response to SARS-CoV-2 with Fast, High-Content Imaging
Experts discuss how automated microscopy and image analysis can quantify critical markers of infection and describe the insight provided by microscopy in the context of SARS-CoV-2 infection and inflammation.
#ExpertAnswers: Emma Karey on E-Cigarettes and Health Risks
Emma Karey challenges the convention that extant cigarette endpoints sufficiently capture the health risks of vaping.
Research Technology & Innovation Summits
The 2022 InsideScientific Research Technology & Innovation Summits focus on specific research and therapeutic areas, reviewing how novel technologies and innovative services are advancing discovery in each particular field.
Assessing Toxicity and Health Risks of E-cigarettes: How to Take Aim at a Moving Target
Dr. Emma Karey presents research that challenges the convention that extant cigarette endpoints sufficiently capture the health risks of vaping, and provides a translational framework for how to integrate scientific principles and novel conditions.
Cutting Edge Conversations: Addressing COVID-19 During Uncertainty
Hayley Crawford, PhD, and Carl Marci, MD, discuss how their specific industries have developed new innovations in response to the COVID-19 pandemic.
#ExpertAnswers: Xuebin Qin on Inflammation and Immunophysiology
Dr. Xuebin Qin talks about his lab’s development and characterization of new models of SARS-CoV-2 and HIV, and how they use these models to study cardiovascular injury associated with infection.
RRSSC – Rodent Inhalation and Injectable Anaesthesia Workshop
This workshop is essential for those who want to gain insight into administering injectable and inhalation anesthetics while monitoring vital physiological parameters in rats and mice.
#ExpertAnswers: P Boon Lim and Melanie Dani on Autonomic Dysfunction in Long-COVID
Experts from Imperial College Healthcare NHS Trust describe the presenting symptoms and diagnostic challenges for patients in their syncope clinic presenting with autonomic dysfunction in Long-COVID.
Autonomic Dysfunction in Long-COVID
During this webinar, experts from Imperial College Healthcare NHS Trust describe the presenting symptoms and diagnostic challenges for patients in their syncope clinic presenting with autonomic dysfunction in Long-COVID.
Evaluation and Optimization of Right Ventricular and Lung Imaging Using High Frequency Ultrasound
Allison Rodgers discusses the value of imaging the mouse right ventricle and lungs using high-frequency ultrasound for models of cardiopulmonary physiology and associated diseases.
Cardiovascular Disease Associated with SARS-CoV-2 and HIV Infections
Dr. Xuebin Qin discusses the development and characterization of new models of SARS-CoV-2 and HIV, and how his lab uses these models to study cardiovascular injury associated with infection.
20 Years of TRPV4: Exploring Science, Discovery, and Future Directions
A virtual conference to celebrate the 20-year anniversary of TRPV4 and discuss its importance across various biological systems and associated disease models.
