Explore CrownBio’s virtual American Diabetes Association 2020 event to catch up with the latest preclinical research on diabetes, NAFLD/NASH, obesity, cardiovascular and renal diseases.
In this free virtual event from June 12–16, CrownBio presented all of the posters they would have presented in person at the American Diabetes Association’s 2020 meeting. The live event is now over, but the resources are now available for viewing on demand.
NASH Day Presentation
Advances in Development of NHP Models of Diet-Enhanced NAFLD/NASH
Friday, June 12 at 11:00 am EDT
Keefe Chng, PhD
Executive Director & Chief Scientific Officer, Crown Bioscience Louisiana
Improved translational models are needed for NAFLD/NASH drug development, to better understand disease progression and accelerate much needed treatment options. In our NASH Day presentation, we’ll explore the characterization of biomarker and histological data supporting observations of NAFLD/NASH in two NHP species on a daily high fat, cholesterol, and fructose diet.
Our data suggest that this diet can be used to rapidly enhance and develop a NHP model of NAFLD/NASH for use in pathophysiology and therapeutic studies. We’ll share histological data demonstrating NAFLD/NASH at 8, 14 and 20 weeks, in comparison with baseline.
ADA Poster: Enhancing NASH in the MS-NASH Mouse through the GAN Diet
Aggravating Liver Lipid Accumulation and Fibrosis in Nonalcoholic Steatohepatitis Model of MS-NASH Mice by a Modified Amylin Diet
Guodong Zhang, PhD
Director, Crown Bioscience Louisiana