In this 2-part webinar, Dr. Dan Burkhoff provides an overview of the fundamental principles of preload, afterload, contractility and lusitropy (diastolic properties), how these are quantified on the pressure-volume diagram, and how they are affected in heart failure.

Part 1: Fundamentals

After reviewing measurement techniques and underlying properties of cardiac muscle and ventricular structure, Dr. Burkhoff demonstrates how pressure-volume analysis can lead to a quantitative understanding of how the heart and vasculature interact to determine stroke volume, cardiac output and blood pressure. The implications for understanding therapeutic effects are also discussed.

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Director of Heart Failure, Hemodynamics and Circulatory Support
Cardiovascular Research Foundation

Production Partner


Harvi is a first-of-its-kind, interactive, dynamic, integrated textbook and simulation-based environment for learning about cardiovascular physiology, hemodynamics and therapeutics. There are several versions of Harvi to choose from that include specific textbooks and simulation options to meet the needs of users with different backgrounds and educational goals.

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