COVID-19, Endotheliitis, & Long-Term Cardiovascular Effects

In this webinar, Dr. Augusto Montezano shares his research that investigates the role of endothelial inflammation and ACE2 biology in COVID-19 infections and long-term effects.

COVID-19 association with cardiovascular disease is thought to be due to endothelial cell inflammation. ACE2 interactions with SARS-CoV-2 spike protein S1 subunit are important to viral infection. In Dr. Montezano’s group, they questioned whether SARS-CoV-2 induces vascular inflammation via ACE2 and whether this is related to viral infection. By exposing human microvascular endothelial cells to recombinant S1p (rS1p), they observed that rS1p induces a potent inflammatory response via an ACE2-dependent manner, without affecting ACE2 activity. Their findings suggest that vascular inflammation in COVID-19 involves activation of ACE2-mediated pro-inflammatory signaling that may be unrelated to viral replication.

Key Topics Include:

Learn a new facet of ACE2 biology
Understand a novel mechanism whereby SARS-CoV-2 spike protein induces endothelial cell inflammation

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Resources

#ExpertAnswers: Guto Montezano on COVID-19 and the Endothelium

COVID-19, Endotheliitis, & Long-Term Cardiovascular Effects from InsideScientific

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Presenters

Augusto Montezano, PhD

Research Associate
Cardiovascular Medicine
McGill University Health Centre

Augusto Montezano completed his PhD (Pharmacology) in 2006, at the University of Sao Paulo, Brazil. In 2018, he became a Walton Fellow in Cardiovascular Medicine at the Institute of Cardiovascular and Medical Sciences at the University of Glasgow. His research focuses on hypertension, vascular calcification and SARS-CoV-2/ACE2 vascular effects.

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