In this webinar, Dr. Augusto Montezano shares his research that investigates the role of endothelial inflammation and ACE2 biology in COVID-19 infections and long-term effects.

COVID-19 association with cardiovascular disease is thought to be due to endothelial cell inflammation. ACE2 interactions with SARS-CoV-2 spike protein S1 subunit are important to viral infection. In Dr. Montezano’s group, they questioned whether SARS-CoV-2 induces vascular inflammation via ACE2 and whether this is related to viral infection. By exposing human microvascular endothelial cells to recombinant S1p (rS1p), they observed that rS1p induces a potent inflammatory response via an ACE2-dependent manner, without affecting ACE2 activity. Their findings suggest that vascular inflammation in COVID-19 involves activation of ACE2-mediated pro-inflammatory signaling that may be unrelated to viral replication.

Key Topics Include:

  • Learn a new facet of ACE2 biology
  • Understand a novel mechanism whereby SARS-CoV-2 spike protein induces endothelial cell inflammation

Resources

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Presenters

Research Associate
Cardiovascular Medicine
McGill University Health Centre

Augusto Montezano completed his PhD (Pharmacology) in 2006, at the University of Sao Paulo, Brazil. In 2018, he became a Walton Fellow in Cardiovascular Medicine at the Institute of Cardiovascular and Medical Sciences at the University of Glasgow. His research focuses on hypertension, vascular calcification and SARS-CoV-2/ACE2 vascular effects.

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