In this webinar, Dr. Augusto Montezano shares his research that investigates the role of endothelial inflammation and ACE2 biology in COVID-19 infections and long-term effects.
COVID-19 association with cardiovascular disease is thought to be due to endothelial cell inflammation. ACE2 interactions with SARS-CoV-2 spike protein S1 subunit are important to viral infection. In Dr. Montezano’s group, they questioned whether SARS-CoV-2 induces vascular inflammation via ACE2 and whether this is related to viral infection. By exposing human microvascular endothelial cells to recombinant S1p (rS1p), they observed that rS1p induces a potent inflammatory response via an ACE2-dependent manner, without affecting ACE2 activity. Their findings suggest that vascular inflammation in COVID-19 involves activation of ACE2-mediated pro-inflammatory signaling that may be unrelated to viral replication.
Key Topics Include:
- Learn a new facet of ACE2 biology
- Understand a novel mechanism whereby SARS-CoV-2 spike protein induces endothelial cell inflammation
To retrieve a PDF copy of the presentation, click on the link below the slide player. From this page, click on the “Download” link to retrieve the file.
McGill University Health Centre