Doppler Flow Velocity Measurements for Cardiovascular Research

Doppler Flow Velocity Measurements for Cardiovascular Research

A unique webinar where experts answer specific questions about best practices and how to apply noninvasive blood flow velocity measurements to your research.

Prior to this event, InsideScientific hosted two webinars focused on noninvasive Doppler blood flow velocity measurement as a means to study cardiac and vascular function in rodents. During these sessions, presenters discussed how Doppler flow velocity can be used to reliably assess systolic and diastolic cardiac function, myocardial perfusion and coronary reserve, pressure overload, aortic stiffness and peripheral perfusion without the need for complex surgery or imaging. Data was also presented highlighting how this measurement can be used to quantify cardiac contractility as a surrogate to +dP/dtmax.

Highlights from these on demand webinars include:

  • Pulsed Doppler Ultrasound – how it works and how it is used
  • An overview of the technology and brief comparison to other modalities
  • Measurements that can be made and their anatomical sites
  • How to calculate pulse wave velocity in mice
  • Introduction to various models including transaortic constriction (TAC)
  • Measuring coronary blood flow and peripheral perfusion
  • Use of Doppler flow velocity as a surrogate to measure contractility as a surrogate to dP/dtmax

During this third installment, sponsored by Indus Instruments, Dr. Anilkumar Reddy of the Baylor College of Medicine returns as a guest presenter along with Ms. Tonya Coulthard, Product Manager at Indus Instruments, to answer questions about how to apply this technology in the lab.  The webinar presented an opportunity to review and delve deeper into previous topics regarding technical and operational features of the technology, how and where to make measurements in order to obtain specific flow signals depending on your research objectives,  and to discuss acquisition, analysis and interpretation of data. 

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Ms. Tonya Coulthard

Product Manager
Indus Instruments

Presenter Bio:

Tonya has a background in Biochemistry (BSc.) and Experimental Medicine (MSc.) and has worked with researchers around the world in a wide variety of disease areas, including cardiovascular disease, for over 10 years. Tonya works with customers at Indus Instruments to understand their specific research applications and to better align product capabilities to their needs ensuring users have success generating data and performing research with their systems.

Dr. Anilkumar K. Reddy

Assistant Professor,
Medicine-Cardiovascular Sciences
Baylor College of Medicine

Presenter Bio:

Dr. Reddy’s current research interests include evaluation of cardiac and vascular mechanics in senescent, disease, transgenic, surgical models of mice. Some of the mouse models he studies include atherosclerosis, dwarf, myocardial infarction/remodeling, pressure overload, hypertension, and absent vascular tone. Using noninvasive methods in his lab, he phenotypes animals as abnormalities develop and progress, and monitors the cardiovascular system as it adapts and compensates for deterioration of function or for missing or over-expressed proteins. The main goal in his laboratory is to translate what is learned in mice to humans for early detection and screening of vascular diseases.