Watch now as Crystal Colón Ortiz, PhD, from the Columbia University Medical Center discusses the inflammatory role of endothelial caspase-9 in neurovascular injury and its contribution to vision changes.
Retinal vein occlusion (RVO) induces pathological consequences including retinal edema, capillary ischemia, and neurodegeneration. In a mouse model of RVO, non-apoptotic expression of endothelial caspase-9 (EC Casp9) can be observed. Knockout of EC Casp9 leads to a decrease in RVO-induced pathology.
In this presentation, Crystal Colón Ortiz describes this mouse model of RVO and discusses known roles of caspases and glial cells in the retina and during vascular injury. Crystal also presents a recent study that reveals that at early time-points post-RVO, EC Casp9 mediates glial changes and promotes high levels of pro-inflammatory cytokines. Behaviorally, this results in contrast sensitivity decline in these animals.
Key Topics Include:
- EC Casp9 leads to increases in reactive microglia
- EC Casp9 triggers astroglial caspase-6 and cleavage of GFAP in RVO
- Deletion of EC Casp9 reduces the expression of inflammatory cytokines and rescues contrast sensitivity decline one day post-RVO
Who Should Attend?
Researchers interested in neuroimmunological disorders, vision science and measuring visual acuity, demyelinating diseases, and aging.
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Columbia University Medical Center