Watch now as Crystal Colón Ortiz, PhD, from the Columbia University Medical Center discusses the inflammatory role of endothelial caspase-9 in neurovascular injury and its contribution to vision changes.

Retinal vein occlusion (RVO) induces pathological consequences including retinal edema, capillary ischemia, and neurodegeneration. In a mouse model of RVO, non-apoptotic expression of endothelial caspase-9 (EC Casp9) can be observed. Knockout of EC Casp9 leads to a decrease in RVO-induced pathology.

In this presentation, Crystal Colón Ortiz describes this mouse model of RVO and discusses known roles of caspases and glial cells in the retina and during vascular injury. Crystal also presents a recent study that reveals that at early time-points post-RVO, EC Casp9 mediates glial changes and promotes high levels of pro-inflammatory cytokines. Behaviorally, this results in contrast sensitivity decline in these animals.

Key Topics Include:

  • EC Casp9 leads to increases in reactive microglia
  • EC Casp9 triggers astroglial caspase-6 and cleavage of GFAP in RVO
  • Deletion of EC Casp9 reduces the expression of inflammatory cytokines and rescues contrast sensitivity decline one day post-RVO

Who Should Attend?

Researchers interested in neuroimmunological disorders, vision science and measuring visual acuity, demyelinating diseases, and aging.

Click to watch the webinar recording. To view the presentation full screen simply click the square icon located in the bottom-right corner of the video-viewer.



Graduate Student
Columbia University Medical Center

Crystal recently defended her PhD thesis in the lab of Dr. Carol Troy at Columbia University Irving Medical Center. During her graduate trajectory, she was awarded with NSF-Graduate Research Fellowship Program, the Association for the American Advancement of Science (AAAS) Program for Excellence in Science, the Society for Neuroscience (SfN) Trainee Professional Development Award, and the NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award.

Webinar Host


Striatech is a young biotech company that spun off from the University of Tübingen, Germany, at the beginning of 2018. The founders – a team of neurobiologists – are all experienced vision researchers and have made it their common goal to make innovative ideas and products from vision and behavioral research accessible to scientists worldwide.

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