Dr. Rohan Virgincar gives insight into the fundamentals of hyperpolarized 129Xe MRI and shares practical considerations for high-resolution imaging in rodent models of lung disease.

Hyperpolarized 129Xe MRI has emerged as a powerful technique to evaluate lung function and has found clinical application in several disorders like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and more. Preclinical 129Xe MRI has the potential to find new applications and accelerate clinical research, but is challenging and limited to only a few centers worldwide.

In this Bruker webinar, Dr. Rohan Virgincar, MRI Applications Scientist at Bruker BioSpin, will give insight into the fundamentals and practical considerations for high-resolution hyperpolarized 129Xe MRI in rodents, based on his 7 years of research in this field at Duke University, USA. He will discuss important factors such as hyperpolarization, xenon gas-delivery using a hyperpolarized-gas-compatible ventilator, imaging considerations for ventilation and dissolved-phase imaging using the 3D ultrashort echo time method, image analysis techniques, and present examples of applications in clinically relevant rodent models of lung disease.

Who Should Attend?

Researchers focused on pulmonary diseases and pulmonary imaging techniques, MRI scientists working with X-nuclei, and those interested in hyperpolarization techniques.



MRI Applications Scientist
Bruker BioSpin

Dr. Rohan Virgincar is an MRI Applications Scientist at Bruker USA. Prior to joining Bruker, he was a graduate student at Duke University, where he gained over 7 years of experience with hyperpolarized gas imaging in the laboratory of Dr. Bastiaan Driehuys, with a focus on preclinical imaging development and applications.

MRI Applications Scientist
Bruker BioSpin

Dr. Kristin Granlund is an MRI Applications Scientist at Bruker USA. Prior to joining Bruker, she was a postdoctoral fellow at Memorial Sloan Kettering Cancer Center. Working with Dr. Kayvan Keshari, she developed methods for imaging in vivo cancer metabolism using hyperpolarized pyruvate.

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Bruker Corporation

Bruker offers preclinical imaging solutions for a broad spectrum of application fields, such as cancer research, neuroimaging and cardiac disease.

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