The intestine communicates with neighboring organs and tissues, including secondary lymphoid tissues, by delivering cells and molecules through the lymphatic or venous vasculature. The architecture of these communications will be introduced and the lecture will proceed to reveal strategies that the intestine uses to limit the dissemination of microbial signals from gut, and the potential proinflammatory effects of this dissemination. Illustrations will be given involving the lymphatic vasculature, and separately, the venous vasculature.

Key Topics Include:

  • The organization of outflow vessels from the intestine and what is known about how this differs over the various regions of the intestine
  • Strategies used by the small intestine to limit dissemination of inflammatory signals in the venous vasculature
  • Strategies used by the small intestine to limit dissemination of inflammatory signals in the lymphatic vasculature
  • Mechanisms underlying pathophysiological remodeling of the lymphatic vasculature draining in the intestine

Presenters

Emil R. Unanue Professor
Department of Pathology and Immunology
Washington University School of Medicine, St Louis

Dr. Gwendalyn Randolph's laboratory considers the impact of how transit of cells and molecules out of tissues influences the inflammatory microenvironment. The lymphatic vasculature is the primary regulator of flux out of tissues and thus we focus on the functionality of the lymphatic vasculature as it relates to the transport of cargo, particularly myeloid antigen-presenting cells in immunity and molecular entities like HDL. In this context, they focus on two chronic inflammatory disease settings, experimental atherosclerosis and inflammatory bowel disease.

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