Watch Dr. Ana Briones present her research on the effects and potential therapeutic targets of excessive inflammation and vascular damage in hypertension.
Inflammation is a typical feature of many cardiovascular diseases such as atherosclerosis, aneurysms, obesity, or hypertension. In hypertension, excessive inflammation from innate and adaptative immune systems associated with elevated levels of local and circulating proinflammatory cytokines and oxidative stress, plays a key role in endothelial dysfunction, vascular remodeling, and augmented vascular stiffness associated to this pathology.
Excessive inflammation can result from elevated cytokines production, but unresolved or inefficient resolution of inflammation might also contribute to the augmented inflammatory milieu found in the vasculature of different cardiovascular diseases. Resolution of inflammation is mediated by a family of specialized pro-resolving mediators (lipoxins, resolvins, protectins, maresins), that limit immune cell infiltration and initiate tissue repair mechanisms.
Dr. Briones shows the latest advances on the role of novel proinflammatory mediators associated to vascular damage in hypertension. Moreover, she discusses the potential beneficial effects of boosting resolution of inflammation as a new therapeutic approach for the treatment of hypertension and vascular alterations.
Key Topics Include:
- To understand the contribution of excessive inflammation to vascular damage in hypertension
- To understand the effects of proresolvin lipid mediators at the vascular level
- To consider resolution of inflammation as a new therapeutic approach for the management of vascular damage associated to hypertension
Universidad Autónoma de Madrid