An Introduction to Isolated Langendorff Heart: Experimental Considerations and Best Practices

An Introduction to Isolated Langendorff Heart: Experimental Considerations and Best Practices

DATE: TUESDAY JULY 30, 2019

TIME: 11:00 EDT  // 17:00 CEST

Join Dr. Melanie White for a discussion on basic isolated Langendorff heart principles, key experimental design considerations, core technology requirements and best practice tips to support consistency and validation of your research.

The isolated Langendorff heart has been a cornerstone of cardiovascular research for more than a century. Its long-standing scientific relevance is partly due to the fact that it allows experimental conditions to be studied beyond confounding hormonal and neurological influence. In addition, the isolated perfused heart serves as a bridge between in vivo and in vitro research, with many applications in heart physiology and pharmacology.

In this webinar sponsored by ADInstruments, Dr. Melanie White, Heart Foundation Future Leader Fellow from the University of Sydney, will provide a useful introduction to isolated heart studies.

Key topics covered during this webinar will include:

  • Understanding the basic principles of isolated Langendorff perfusion
  • Experimental design considerations
  • How to set up your hardware to ensure your experiments are trouble-free
  • Tips for data analysis
  • Examples of how Langendorff is used to look at myocardial ischemia and diabetic cardiomyopathy

Melanie White, PhD

Heart Foundation Future Leader Fellow
The University of Sydney School of Medicine

Dr. Melanie White is a member of the Charles Perkins Society, a Heart Foundation Future Leader Fellow and teaches senior students in the discipline of Pathology at the University of Sydney School of Medicine. Her research interests include understanding more about how cells adapt to their changing environment by altering proteins using post-translational modifications. Her and her team’s work centers on asking these questions in clinically relevant models of myocardial ischemia (heart attack), type 2 diabetes and obesity.