Scientists present groundbreaking research in models of Acute Kidney Injury (AKI). Methods used to gather these insights are made possible using the latest in fibre optic sensing technology to obtain dissolved oxygen and microvascular blood perfusion at the tissue level.
The survival of tissues and organs relies on an adequate supply of oxygen, nutrients and signal molecules delivered via microvascular blood perfusion. The measurement of microvascular perfusion provides critical information for research applications where blood supply has been disrupted. In addition, tissue oxygen tension (ptiO2) can be measured at the cellular level as a read-out of the balance between oxygen availability and metabolic oxygen consumption. Combining these measurements gives the researcher a very powerful and unique tool to answer questions in the areas of physiology, oncology, cerebral monitoring, ischemia/reperfusion, ophthalmology and many more.
During this webinar sponsored by Scintica Instrumentation, Professor Clive May and Dr. Yugeesh Lankadeva from the Florey Institute of Neuroscience and Mental Health in Melbourne discuss their research using Oxford Optronix OxyFlo™ and OxyLite™ tissue vitality monitoring systems to investigate the causes of acute renal failure in large animal models and the effects of resuscitation with vasopressor drugs on renal perfusion and oxygenation in sepsis.
Specifically, they discuss the development and validation of methodology to measure renal cortical and medullary tissue perfusion and oxygenation long-term in conscious animals and review selective changes in renal cortical and medullary tissue perfusion and oxygenation in response to alterations in total organ blood flow and administration of drugs.
In addition, Professor May and Dr. Lankadeva share data from their studies demonstrating changes in total renal blood flow, renal function and differential changes in renal perfusion and pO2 during resuscitation and in models of sepsis.
Future Leader Fellow
Florey Institute of Neuroscience and Mental Health