Positron emission tomography (PET) is a powerful, sophisticated technique that enables the acquisition of comprehensive data in a range of neuroimaging applications.

In this webinar, PET experts Dr. Michael Placzek, and Dr. Joseph Mandeville will provide an overview of their current projects, centring around the core principles of PET and MRI occupancy studies, the relevance to their work, and other applications. By using practical examples from their own innovative research, the pair will explore a range of approaches to using PET in preclinical neuroimaging, exploring the benefits, challenges and exciting potential of this imaging technique. They will also outline how their respective technical and image analysis capabilities have developed over time, and give an overview of their approaches to data processing, image analysis, and automation.

Key Topics Include:

  • A general summary of PET imaging’s application in preclinical neuroimaging studies
  • Challenges common in PET imaging
  • Designing studies in order to maximize sensitivity
  • Translational study approaches linking small and large animal studies
  • PET imaging applications in the field of drug discovery
  • An introduction to challenge design concepts
  • Approaches to increasing throughput and efficiency using automation

Who Should Attend?

This webinar will be of particular interest to researchers, principal investigators, and postgraduate students working in academia, as well as researchers in the pharmaceutical industry, particularly those working in drug development, and those working with small animal models.

Presenters

Michael Placzek, ;PhD

Michael Placzek, PhD

Assistant Professor in Radiology
Harvard Medical School
The Martinos Center for Biomedical Imaging

Dr. Michael Placzek, PhD is an Assistant Professor in Radiology at Harvard Medical School and Martinos Center for Biomedical Imaging at Massachusetts General Hospital. Michael is the Director of Pharmacology at Martinos Center Chemical Neuroscience Program where he focuses on early-phase translational neuroimaging - from chemical discovery to preclinical neuroimaging. Michael has active projects in opioid pharmacology and neural signaling with MR-PET - including kappa opioid receptor drug occupancy studies in rodents. Michael also directs discovery projects with a focus on developing CNS PET radiotracers that target the neuroimmune system as it relates to neurodegenerative disease.
Joseph B. Mandeville, ;PhD

Joseph B. Mandeville, PhD

Biomedical Researcher
The Martinos Center for Biomedical Imaging

Dr. Mandeville received a PhD in nuclear physics from the University of Illinois in 1993 and has since worked at the Martinos Center for Biomedical Imaging at the Massachusetts General Hospital. His interest is the development, refinement, and characterization of neuroimaging methods. His early worked focused on functional MRI, particularly using exogenous contrast agents. His recent interests include simultaneous PET/fMRI applications that seek to provide an enhanced picture of neural function by correlating induced hemodynamic responses with neuroreceptor occupancy.
Geoff Warnock, ;PhD

Geoff Warnock, PhD

Senior Applications Scientist
PMOD Technologies

Geoff Warnock is Senior Application Scientist at PMOD Technologies, part of Bruker since July 2019. PMOD provides solutions for all stages of quantitative data processing, and specializes in PET kinetic modeling. Geoff has focused on quantitative PET for more than 10 years, and provides customized training courses to PMOD’s customers around the world.
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Webinar Host

Bruker Corporation

Bruker offers preclinical imaging solutions for a broad spectrum of application fields, such as cancer research, neuroimaging and cardiac disease.

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