Scientists present data on 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed, awake and behaving mice.

Head fixation is a powerful approach for studying the rodent brain in vivo. Stabilizing the head of a freely moving and behaving animal allows the researchers to study neuronal activity using single-cell electrophysiology and 2-photon imaging. These movement-sensitive techniques are inherently challenging for experiments with behaving rodents, unless they are aided by instrumentation that provides both stability and stress-reduction.

In this webinar sponsored by Neurotar, experts present their research on 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed awake behaving mice. Dr. Konrad Juczewski from the National Institutes of Health (NIH)/National Institute on Alcohol Abuse and Alcoholism (NIAAA) discusses the impact of head fixation on animal’s stress, locomotion and performance in classical behavioral paradigms.

Dr. Mary Ann Go from the Laboratory of Neural Coding and Neurodegenerative Disease at Imperial College London led by Prof. Simon Schultz presents her research using 2-photon microscopy aimed at place cell mapping in the hippocampus during exploration and navigation of a circular linear track.

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Presenters

Post Doctoral Fellow
National Institutes of Health (NIH)

Post Doctoral Researcher
Neural Coding and Neurodegenerative Disease Laboratory
Imperial College London

Production Partner

Neurotar

Neurotar develops instrumentation for microscopic imaging and electrophysiological recordings in the brain of awake head-fixed mice. Its proprietary Mobile HomeCage® allows integrating high-precision tests with behavior, starting from simple locomotion tracking to maze navigation. Neurotar has extensive imaging experience: the company pioneered in vivo two-photon imaging as contract research for the pharmaceutical industry in 2010. It has since extended its service portfolio to imaging studies in awake behaving mice.

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