Best-Practices to Achieve Quality Pressure-Volume Loop Data in Large Animal Models

Best-Practices to Achieve Quality Pressure-Volume Loop Data in Large Animal Models

A webinar discussing methodology, best-practices and prescribed techniques for accurate and repeatable collection of pressure-volume loop data in large animal models of cardiac dysfunction and heart disease.

Large animal hemodynamic research models are on the rise. They are increasingly used in various preclinical studies including pharmaco-safety and drug discovery assessment, ventricular assist-device testing and models of pulmonary artery hyperthrophy and right ventricular overload. Important to these applications and all cardiovascular studies is the collection of both central and peripheral hemodynamics, with a focus on instantaneous pressure and volume measurements from the beating heart (PV Loops). Only with PV loops can scientists obtain the most comprehensive evaluation of cardiac function. It is therefore critical for cardiovascular scientists to understand how PV Loop data should be collected along with these peripheral hemodynamic measurements. This webinar aims to discuss these essential elements and how they should be applied.

During this webinar sponsored by TransonicDr. Tim Hacker and Dr. Filip Konecny present common hemodynamic set ups for large animal models. Using case studies from dogs and swine models, they show surgical best-practices, tips for catheter navigation and how to correctly position a PV-catheter in the left or right ventricle. In addition, they explain how researchers can verify accurate and reliable PV loop data at the bench-side.

Key topics in this webinar include…

  • Essential hemodynamic equipment and technology
  • Anaesthetic and drug considerations for large animal PV studies
  • Surgical approaches — which one is best for you?
  • How to successfully navigate the PV catheter and validate correct position in the ventricle
  • Right ventricle PV loops — important surgical, data collection and analysis considerations
  • Unique attributes of ‘admittance’ derived volume

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Tim Hacker, PhD

Cardiovascular Physiology Core,
The University of Wisconsin-Madison

Filip Konecny, DVM PhD

Application Scientist
and Surgical Trainer,