Wireless Recording Technologies for in vivo Electrophysiology in Conscious, Freely Behaving Non-Human Primates

Wireless Recording Technologies for in vivo Electrophysiology in Conscious, Freely Behaving Non-Human Primates

DATE: TUESDAY, JANUARY 30, 2018

TIME: 11:00 AM – 12:00 PM EST (UTC -5)

Scientists discuss technological advancements and present novel application of new head-mounted and implantable, wireless sensors for neural recording in non-human primates.   

Rapid innovation in sensor miniaturization and novel integration of head-mounted, implantable wireless technologies with electrode interfaces has enabled scientists to investigate neuronal processes in greater detail than ever before. Neural recordings including up to 128 channels of real time EEG, ECoG, EMG, ECG and single unit/spike signals for telemetric experiments are no longer an obstacle.  The application of these ground-breaking technologies is helping clarify the complex nature of various neuronal diseases, and identify novel treatment methods.

During this webinar, sponsored by Triangle BioSystems International (TBSI), scientists will present experimental methods and scientific findings from applications of in vivo electrophysiology in conscious non-human primates using new head-mounted, wireless sensors.

Specifically, scientists from The Hatsopoulos Laboratory at the University of Chicago will present research using a 64 channel wireless headstage on marmosets.  The objective of this research is to investigate sensorimotor encoding across marmoset’s behavioral repertoire.  The group will discuss the platform they have developed for voluntary behavioural training and neural recording in a home cage environment, and share some preliminary data they have obtained.

Following representatives from Dr. Ben Hayden’s lab, at the University of Minnesota, will present a case study in which they have successfully implemented the 128 channel headstage in macaques while performing a center-out joystick task in a primate chair. They will share methodology, experimental design, and discuss the promise their results show for future studies using untethered wireless recordings in freely moving and behaving animals.

ASSOCIATED EVENT: Wireless Recording and Stimulation Technologies for in vivo Electrophysiology in Conscious, Freely Behaving Rodents

Dr. Melissa Caras and Dr. Dan Sanes, from the Centre for Neural Science at New York University, present a case study on auditory cortex recordings collected from freely moving gerbils during learning and task performance. They will share methodology, resulting discoveries, and discuss the importance of within-animal, real-time comparisons of neural and behavioral measures. Following, Bradly Barth presents experimentation conducted in Dr. Xiling Shen’s laboratory at Duke University, where they have achieved successful stimulation of the sacral nerve in conscious, freely-moving, untethered mice using a hermetic, fully-implantable, wireless nerve stimulator from TBSI.  WATCH ON DEMAND

Presenters:

The Hatsopoulos Laboratory at the University of Chicago focuses on research on the neural basis of motor control and learning. They are investigating what features of motor behavior are encoded and how this information is represented in the collective activity of neuronal ensembles in the motor cortex, premotor, and somatosensory cortices. They are also interested in what ways these change as motor learning occurs. The approach they take has been to simultaneously record neural activity from large groups of neurons using multi-electrode arrays while performing detailed kinematic, kinetic, and muscle measurements of goal-directed, motor behaviors, and to develop mathematical models that relate neural activity with behavior.

Dr. Nicho Hatsopoulos

Associate Professor
University of Chicago

Jeff Walker

Graduate Student
Dr. Hatsopoulos Laboratory
University of Chicago

The Hayden Laboratory from the University of Minnesota focuses on the neural basis of choice. Ranging from neuroeconomics and self control, to curiosity and disease. Their research into neural basis of choice has direct implications on many deep philosophical questions, especially as they relate to free will. They study how our brains compare different options and choose the most rewarding ones. The team records the activity of single neurons during real choices in order to parcel out the contributions of frontal lobe structures to reward-based choices.

Dr. Benjamin Hayden

Assistant Professor
Department of Neuroscience
University of Minnesota

Dr. Adam Rouse

Research Assistant Professor
Department of Neuroscience
University of Rochester

Seng Bum (Michael) Yoo

Ph.D. Student
Department of Brain and Cognitive Science
University of Rochester

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