Novel Method for Superior Lead Optimisation – Application to the Antiviral AZT

Novel Method for Superior Lead Optimisation – Application to the Antiviral AZT

ON DEMAND

Scientists discuss the use of NMR to analyze the antiviral drug Azidothymidine AZT, a medication currently used to prevent and treat HIV/AIDS.

Lead optimization in drug discovery has changed significantly during the last few years. Structural information on ligand-protein complexes, at atomic resolution, is considered to be extremely important to improve binding affinity. Moreover, the nature and energy of conformational changes of the free ligand in solution, can drive the binding recognition procedure, improving binding efficacy overall.

In this Bruker webinar, Dr. Armando Navarro will discuss the analysis of the antiviral drug Azidothymidine AZT (or Zidovudine ZDT). This compound is used as antiretroviral medication to prevent and treat HIV/AIDS and how to combine different NMR observables (NOE, J-couplings, chemical shifts…) for a more accurate conformational analysis.

Presenters:

Dr. Armando Navarro
MRI Applications Scientist
Bruker

Armando Navarro got his PhD. in chemistry at the University of Santiago de Compostela. After his post-doctoral studies in the Institut für Organische Chemie he joined the University of Santiago de Compostela where he worked in the development of NMR oriented software. He moved later to the University of Vigo and in 2014 he moved to the University Federal of Pernambuco where he holds currently a full professorship. His research is focused in the development of computational strategies and materials applied the structural elucidation of organic compounds.

Dr. Matteo Pennestri
NMR Specialist and Product Manager
Bruker

Matteo Pennestri obtained his Ph.D. in Biophysical methods at the University of Tor Vergata Rome (collaboration with Merck Sharp and Dohme). Then he moved as NMR spectroscopist in the pharmaceutical industry (MSD and EISAI). After experiencing the pharma sector, he joined as application scientist Agilent Technologies first (ex. Varian) and Bruker afterwards. Recently he joined the Bruker Pharma unit as NMR specialist and product manager.

Other Webinars in this Series…

Treatments of COVID-19: Old Drugs, New Tricks

Treatments of COVID-19: Old Drugs, New Tricks

ON DEMAND

Dr. Niamh O'Boyle, from Trinity College in Dublin, provides an overview of the SARS-CoV-2 virus and discusses the drugs that are currently in use to treat COVID-19.

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