Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.

Novel environments (cage changes), traditional handling, restraint methods, and even the presence of humans can cause stress to laboratory animals. Minimizing stress to animals throughout the duration of a study is key to generating accurate, reproducible data while also improving animal welfare. BASi’s RaturnTM is a movement responsive caging system that facilitates data collection in awake, freely moving rodents without the need for human intervention! Unlike swivels, this allows for simultaneous collection of multiple types of data that can be obtained from study animals, making it a useful tool for any researcher conducting tether-based studies.

During this webinar sponsored by BASi, Candace Rohde-Johnson will discuss how tethering systems can be used as a hands-off approach to data collection for research applications including microdialysis, open flow microperfusion, telemetry and optogenetics.

Following, Dr. John Cirrito, leading Alzheimer’s disease researcher and professor at Washington University of St. Louis, will present an overview of the data his team has collected through an in vivo microdialysis technique that enables minute-to-minute measurement of interstitial fluid (ISF) Aβ within the brains of awake and behaving mice. He will also share additional study applications made possible by using the RaturnTM system.

 

Research Applications:

  • Addiction
  • Anesthesiology
  • Behavioral Neuroscience
  • Cardiovascular
  • Inflammatory Disease
  • Metabolic Disease
  • Neuroscience
  • Ocular Disease/Function
  • Oncology
  • Pain
  • Pharmacokinetics
  • Renal Physiology
  • Reproductive Toxicology
  • Safety Pharmacology
  • Sleep
  • Toxicology

Measurement Techniques:

  • Microdialysis
  • Open Flow Microperfusion
  • Optogenetics
  • Fiber Photometry
  • Neuronal Biopotentials (e-phys)
  • Blood Sampling
  • Microinfusion
  • Microinjection
  • EEG
  • EMG
  • Drug Infusion
  • Activity Monitoring
  • Commutators
  • Swivels
  • Telemetry

Key Topics Include:

  • The impact of human presence on data collection in lab animals
  • How the RaturnTM can increase flexibility in study design and advanced applications
  • The relationship between synaptic transmission and ISF Aβ levels

Resources

Presenters

Associate Professor of Neurology
Washington University in St. Louis

Director of in Vivo Products and Services
BASi

Production Partner

BASi – Bioanalytical Systems, Inc.

BASi provides drug developers with superior scientific research and innovative analytical instrumentation, which saves time, saves money, and saves lives, to bring revolutionary new drugs to market quickly and safely.

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