Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design

Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design

An in-depth exploration of ventricular pressure-volume catheter calibration parameters, considerations for experimental design and their effects on your pressure-volume data.

Cardiovascular researchers interested in acquiring baseline and load-independent ventricular pressure-volume data face a multitude of questions regarding technology, calibration and experimental design. Focusing on results and keeping the end in mind is often where the best answers lie.

In this webinar sponsored by ADInstruments, Dr. Dimitrios “Jim” Georgakopoulos — an expert in the theory, history and application of ventricular pressure-volume science — discusses conductance-based pressure-volume technology, the theory and importance behind resistivity and parallel volume calibration factors, how experimental conditions can (and should) influence your approach and the significance of proper calibration in acquiring quality results.

Key topics covered in this webinar include…

  • Ventricular pressure volume calibration theory
  • Designing a PV Loop experiment with the end in mind
  • Parallel volume calibration
  • Resistivity or conductance calibration
  • Markers for quality and reliable pressure-volume data

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Dimitrios “Jim” Georgakopoulos, PhD

Chief Scientific Officer,
Sunshine Heart

Dr. Georgakopoulos started his PV loop research in 1994 alongside David Kass. Over the next 10 years together they worked on many “firsts” relating to PV Loop science, including development of the first systems and methodologies for obtaining PV loops in the mouse. In fact, they were the first to publish data showing PV loops collected in an animal model of this size. They went on to study force-frequency relations in the mouse model assessing calcium dynamics in vivo, and also studied the role of nitric oxide and neural control of the circulation through the baroreflex.


Following Dr. Georgakopoulos went on to join CVRx, which at the time was developing a device to electrically stimulate the baroreflex for the treatment of hypertension and heart failure. In this position he utilized PV loops to study the effects of the device and published the first human PV loop recordings showing combined electrical stimulation of the baroeflex.

In his current position at Sunshine Heart he is engaged in the development of a device targeted to assist the failing heart in advanced heart failure patients. Specifically, the device consists of a cuff which is wrapped around the ascending aorta providing chronic counterpulsation. Interestingly, they believe that some of the effects of mechanically compressing the aorta may be due to aortic baroreceptor stimulation, therefore they are are employing PV loops to separate the effects on the heart and coronary circulation from the peripheral vasculature.