When planning pharmacological experiments using small animals, the method and schedule of drug administration are critical factors that must be taken into account.
This white paper highlights the importance of choosing an appropriate drug delivery method to optimize pharmacological efficacy and reduce harm to the animal.
Compared to humans, small animals such as mice and rats distribute, metabolize and eliminate pharmacological agents much faster. If a drug’s half-life is short, administration via injection can be impractical and even harmful: a frequent injection schedule leads to excess handling, labor and planning from the researcher. This can lead to increased stress and drug toxicity in the animal, and a reduction in drug efficacy.
This white paper addresses this pharmacological challenge, discussing how continuous infusion using ALZET Osmotic Pumps can increase efficacy, reduce side effects, or both. It describes how the schedule and method of administration can influence a drug’s therapeutic index and presents 6 research case studies comparing the efficacy of different delivery methods in small animal models, primarily bolus injection and continuous infusion.
Below is a spoiler-free summary of each pharmacological case study.
This white paper is most valuable to pharmacological researchers interested in understanding how drug regimen can affect therapeutic index and learning how they can optimize drug efficacy, reduce side effects and minimize animal stress due to serial injections and handling.
Complete the form below to receive a PDF copy of the White Paper.
To learn more about the use of implantable pumps as an alternative to serial injections for pharmacological research, watch the webinar
Compound Delivery, PK-PD, & Validation Studies in Oncology Research
Dr. Christian Schnell describes his work involving implantable infusion pump studies in rodents and the advancement of pharmacological interventions in oncology research.
Implantable Infusion Pumps: Insights For Your Next Animal Dosing Study
José Gadea clarifies common misconceptions surrounding the use of implantable pumps and present the facts to support their value in preclinical research.