Compared to humans, small animals such as mice and rats distribute, metabolize and eliminate pharmacological agents much faster. If a drug’s half-life is short, administration via injection can be impractical and even harmful: a frequent injection schedule leads to excess handling, labor and planning from the researcher. This can lead to increased stress and drug toxicity in the animal, and a reduction in drug efficacy.
This white paper addresses this pharmacological challenge, discussing how continuous infusion using ALZET Osmotic Pumps can increase efficacy, reduce side effects, or both. It describes how the schedule and method of administration can influence a drug’s therapeutic index and presents 6 research case studies comparing the efficacy of different delivery methods in small animal models, primarily bolus injection and continuous infusion.
Below is a spoiler-free summary of each pharmacological case study.