Join Dr. Srivalleesha Mallidi as she discusses advances in pancreatic cancer therapies using ultrasound-guided photoacoustic imaging.

Pancreatic cancer is a disease with an incredibly poor survival rate. As only about 20% of patients are eligible for surgical resection, neoadjuvant treatments that can relieve symptoms and shrink tumors for surgical resection become critical. Many forms of treatments rely on increased vulnerability of cancerous cells, but tumors or regions within the tumors that may be hypoxic could be drug resistant. Particularly for neoadjuvant therapies such as the tyrosine kinase inhibitors utilized to shrink tumors, it is critical to monitor changes in vascular function and hypoxia to predict treatment efficacy.

Current clinical imaging modalities used to obtain structural and functional information regarding hypoxia or oxygen saturation (StO2) do not provide sufficient depth penetration or require the use of exogenous contrast agents. In the second episode of the Vevo 4 Oncology Web Series, Dr. Mallidi will discuss the use of ultrasound-guided photoacoustic imaging (US-PAI), which has recently garnered significant popularity as it can noninvasively provide multiparametric information on tumor vasculature and function without the need for contrast agents.

Key Topics Include:

  • Demonstrate the importance of changes in StO2 values to predict treatment response, particularly tumor growth rate, when the outcomes are suboptimal in treatments such as photodynamic therapy and tyrosine kinase inhibitor cabozantinib
  • Utilize the US-PAI data to develop a multivariate regression model that demonstrates that a therapy-induced reduction in tumor growth rate
  • Showcase the utility of photoacoustic surrogate markers for treatment design

Presenters

Srivalleesha Mallidi, ;MS, PhD

Srivalleesha Mallidi, MS, PhD

Assistant Professor
Biomedical Engineering
Tufts University

Srivalleesha (Valli) Mallidi obtained her M.S. and Ph.D. degrees in Biomedical Engineering from University of Texas at Austin. She worked in the Ultrasound imaging group of Prof. Stanislav Emelianov. Dr. Mallidi master’s thesis involved custom designing ultrasound based multi-modality imaging systems while her doctoral work explored the utility of surface plasmon resonance properties of spherical gold nanoparticles for early detection of cancer and probing nano-molecular interactions. Her graduate work is published in journals such as Nanoletters and Optics Express. Her work on Molecular specific photoacoustic imaging is highly cited.
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FUJIFILM VisualSonics Inc.

FUJIFILM VisualSonics designs and manufactures ultra high frequency in vivo imaging systems, for both research and clinical use. our ultrasound platform provides images at resolutions that far exceed any other system available on the market. Beyond ultrasound, we have also developed a unique photoacoustic technology to expand on the capabilities of our imaging solutions.

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