Carl Petersen and Alexei Verkhratsky share their research on homeostatic neuroglia and imaging of neuronal network function.
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Animal Model Selection, Study Design and Current Trends in Preclinical Obesity Research
OBESITY SERIES 2020: Dr. Fred Beasley provides an overview of study design, criteria for defining your study aim and expert advice for selecting the ideal rodent model for your preclinical obesity research.
From Pregnancy to Menopause: Studies of Physical Activity, Behavior, and Energy Balance in Mice
THU, OCT 1, 2020
Sharon Ladyman and Vicki Vieira-Potter share their research on the effects of hormones and pregnancy on daily activity in mice.
Studying Epilepsy in Awake Head-Fixed Mice Using Microscopy, Electrophysiology, and Optogenetics
Experts discuss how microscopy, electrophysiology, and optogenetics are used to study microglial calcium signaling and epileptic networks in awake head-fixed mice.
In-Situ Electrochemical EPR for Real-Time Measurements of Radical Ions
TUE, OCT 27, 2020
Dr. Raanan Carmieli discusses the use of electron paramagnetic resonance (EPR) as a powerful technique for the study of transition metals, organic radical ions and transient radical-pairs in photoexcited systems.
Data Collection & Analysis in Human Autonomic Research: How to Guide Successful Testing
Dr. Jackie Limberg discusses the basics of human autonomic research and shares tips & tricks for data collection and analysis during human autonomic testing to improve the accuracy and reliability of your findings.
Obesity Webinar Series 2020
A webinar series focused on late-breaking research and discovery relating to the physiological mechanisms of obesity-related disease.
Case Studies in Home Cage Monitoring: Rodent Behavior, Circadian Biology and Animal Welfare
Joanna Moore and Kenneth Dyar present applications of the DVC® system from different research perspectives and discuss how home cage monitoring can be used to study animal model development, physiology and behavior.
Introduction to CEST for MRI Assessment of Brain Ischemia and Cancer Lesions
ON DEMAND
Dr. Marty Pagel introduces the CEST MRI technique, demonstrates a basic experiment, and explains why measuring protein, acid, and metabolite content can be so beneficial in applications of brain ischemia and cancer.
Mitochondrial Membrane Lipids and Respiratory Efficiency
OBESITY SERIES 2020: Join Katsu Funai to learn how mitochondrial membrane lipids can affect metabolic efficiency and propensity for obesity-related diseases.
Cardiovascular Autonomic Testing Revisited
Dr. Artur Fedorowski outlines the practical skills needed to perform a successful cardiovascular and autonomic workup in unexplained syncope and cardiovascular dysautonomia.
Decoding Turbulent Chemical Plumes with Improved Signal Processing and Machine Learning
Join Dr. Burgués as he demonstrates how he has built faster and more reliable MOX sensors for tracking turbulent chemical plumes.
Comparability studies of Pharmaceutical Proteins by 2D NMR fingerprint
Dr. Malmstrøm demonstrates how correlations between NMR data and bioactivity can be used to confirm the structure and activity of proteins.
Cravings and Weightlifting Squats: Technologies that Explore New Metabolic and Behavioral Research
OBESITY SERIES 2020: Zhen Yan and Diego Bohórquez present case studies demonstrating the use of automated home cage phenotyping for preclinical obesity research.
Solid-state NMR Spectroscopy in Pharmaceutical Sciences from Drug Delivery to Formulation Development
Join Dr. Yongchao Su for an overview of the versatile roles of ssNMR in pharmaceutical development, providing a structural basis for the design of drug substances and products.
An Improved Method for Studying Mouse Diaphragm Function
VIRTUAL POSTER
A detailed and ready-to-use protocol on the design and manufacturing of diaphragm clamps, and how to mount them to a muscle force measurement system.
COVID-19 – What’s NMR got to do with it?
Dr. Sharman explains the impact of using NMR for the quality control and release of drug molecules currently in shortage due to the Coronavirus pandemic.
How to Record Great Respiration Data
Join BIOPAC to learn more about technologies and techniques to help you record good quality respiration data.
Considerations for Rigorous Pre-clinical Studies in Murine Muscular Dystrophy
Experts present key considerations in the design of rigorous preclinical studies in rodent models of muscular dystrophy, including animal model selection, assays and endpoints, and how your results can inform translation to the clinic.
Characterizing Pharmaceutical Formulations Using Solid-State NMR Spectroscopy
An expert in pharmaceutical sciences discusses solid-state NMR spectroscopy as an advanced analytical technique to provide unique insight into the composition and properties of pharmaceutical formulations.
Clinical Methods and Applications of Hyperpolarized 129Xe MRI for Functional Imaging of the Lungs and Other Organs
Renowned MRI expert, Prof. Jim Wild, will discuss the clinical applications of 129Xe lung imaging with a focus on novel pulmonary therapies using hyperpolarized gas and proton lung MRI as markers.
Heterogeneity and Crosstalk of Human Brown Adipose Tissue
OBESITY SERIES 2020: Camilla Schéele & Christian Wolfrum discuss the physiology of brown adipose tissue and share late-breaking research on the role of BAT in whole body metabolic regulation.
Perception and Encoding of Temporally Patterned Odour Stimuli in Mice
VIRTUAL POSTER
Dr. Dasgupta explains his unique methodology and applications for analyzing the temporal structure of odour plumes.
Micro-CT: Fancy gadget or indispensable technology towards accurate quantification of lung disease and therapy?
An infectious lung disease expert shares compelling evidence for the use of micro-CT to repeatedly evaluate disease progression and therapy efficacy in live animals.
Endocytosis and Endosome Trafficking: Roles in Coronavirus Uptake and Cell Signaling
Ole Petersen, Roop Mallik and Erwin Neher share the latest research looking at endocytosis and calcium signaling in the context of SARS-CoV-19, organelle transport and calcium imaging.
Functional Ultrasound (fUS) Imaging in the Brain of Awake Behaving Mice
Experts discuss how functional ultrasound imaging in awake head-fixed mice can help advance basic neuroscience and neurovascular research, as well as preclinical drug discovery.
Hybrid PET/MR Enables Exploration of New Science Areas
Experts discuss the synergies and implementation of state-of-the-art hybrid PET/MR technology and the new avenues of exploration it affords in the fields of neuroscience, cancer, and metabolic disease through to dual molecular probe development.
Calories, Carbs, or Quality? What Matters Most for Body Weight
OBESITY SERIES 2020: Kevin Hall, PhD discusses the physiology of body weight regulation and how dietary factors like amount of carbs, fat and "ultra-processed" foods affect human body weight.
Utilizing Stable Isotope Tracers in Preclinical Models of Obesity
OBESITY SERIES 2020: Marshall McCue, PhD presents case studies using small mammals where 13C-labeled nutrient oxidation is tracked second-by-second in real-time using the newest laser-based stable isotope approaches.
ADA 2020 CrownBio Virtual Event
Explore CrownBio's virtual American Diabetes Association 2020 event to catch up with the latest preclinical research on diabetes, NAFLD/NASH, obesity, cardiovascular and renal diseases.
Brain Circuits Driving Appetite
OBESITY SERIES 2020: Lora Heisler, PhD discusses the unique brain circuits that are controllers of body weight, reviews how our genes impact our waistline and explains how obesity medications leverage basic neurobiology to reduce hunger and decrease body weight.
Introduction to Antibodies and Their Analytical Characterization
An expert from AstraZeneca will discuss the use of antibody drugs, how they function and the different techniques used to characterize them in the drug development process.
VO2 MAX Test Optimization for Cardiometabolic Phenotyping in Rodents
Attend this webinar to learn how VO2max exercise testing can be used to assess the cardiometabolic phenotype of rodents.
MicroCT Applications in Lung Research and Immunology
Dr. Redente discusses the advantages of microCT and provides a broad overview of pulmonary disease imaging using a highly innovate technique to analyze living animals, as well as fixed tissue.
Infectious Disease Research: A Holistic Approach to Physiologic Data Collection and Model Development
Join Dr. Anna Honko and Dr. Doug Reed as they discuss methods and applications for infectious disease research including coronavirus-based illnesses.
PET Image Reconstruction Overview – Current and Future Trends
Experts provide a guided tour to PET image reconstruction for the application-oriented user. They share the pros and cons, and give you a glimpse of what to expect in the future with exciting insights into future trends.
Improving Animal Modeling with 24/7 Home Cage Monitoring in Bioexclusion & Biocontainment Mouse Housing Systems
Experts discuss current biosafety requirements and what home cage monitoring can teach us in bioexclusion and biocontainment studies.
Cardiac PV Loop Data Analysis: Tips & Tricks
Dr. DeWayne Townsend and Dr. Adam Goodwill discuss the fundamentals of pressure-volume loop analysis as a means to study cardiac function.
Novel Method for Superior Lead Optimisation – Application to the Antiviral AZT
Scientists discuss the use of NMR to analyze the antiviral drug Azidothymidine AZT, a medication currently used to prevent and treat HIV/AIDS.
A New Frontier of Precision Medicine: Using PET for Image-Guided Neurointerventions
Experts discuss how PET/CT imaging can be used to enable image-guided neurointerventions and to study targeted delivery and clearance of therapeutic agents.
Optogenetics Telemetry – Shining a Light on Long-Term Optogenetic Stimulation with Telemetry
Dr. Sarah-Jane Guild provides an introduction to optogenetics, discusses the advantages of implantable optogenetics telemetry and reviews data collection using the Kaha Sciences Optogenetics system.
Hyperpolarized Xe MRI of Pulmonary Gas-Exchange in Rodents
Dr. Rohan Virgincar gives insight into the fundamentals of hyperpolarized 129Xe MRI and shares practical considerations for high-resolution imaging in rodent models of lung disease.
Rapid Narcotics Analysis by Orthogonal Methods: MS meets NMR
Experts discuss the ease of use and advantages to using a harmonized approach of Nuclear Magnetic Resonance and Mass Spectroscopy for the detection and identification of narcotics.
NMR Characterization of Polysaccharide-Based Vaccines
Dr. Francesco Berti describes the use of proton NMR for structural identity and conformity testing of carbohydrate-based vaccines.
Ensuring Quantitative Accuracy in PET
NMI experts describe quality control procedures and image corrections for the Bruker PET technology, demonstrate image transfer to PMOD for analysis and outline best practices to ensure good quantitative PET.
Biofeedback + VR + Physiology Technical Showcase
Join BIOPAC to learn how you can get started with your own physiology research using VR, what options are available and how to create a virtual environment for physiology experiments.
Treatments of COVID-19: Old Drugs, New Tricks
Dr. Niamh O'Boyle, from Trinity College in Dublin, provides an overview of the SARS-CoV-2 virus and discusses the drugs that are currently in use to treat COVID-19.
The Use of Home Cage Monitoring to Determine Whether Individual Male Mouse Activity Patterns Correlate with Nest Complexity
VIRTUAL POSTER
It is well established that nesting materials are an important inclusion for mouse cages. We wanted to determine whether there was a significant difference in mice activity when offered three different material choices and whether there was any correlation between activity in the cage and nest complexity.
Identifying Preclinical Immunotherapy Candidates Using a NHP Exploratory Toxicology Platform
Dr. Thomas Scullion discusses how to leverage NHP exploratory toxicology studies to guide and explore lead optimization, dosing paradigms, and future GLP studies.
Measuring Visual Acuity and Contrast Sensitivity by Optomotor Reflex in Rodents
Experts discuss case studies and experimental data from various applications using a newly developed automated system to measure vision based on the optomotor reflex.
Locomotor Activity: refinement, reduction and replicability ‘round the clock in animal studies
VIRTUAL POSTER
A growing body of evidence suggests that Home Cage Monitoring studies are becoming key tools for in vivo animal research for three main reasons: reduction in animal distress thereby increasing welfare, minimization of biases (wanted and unwanted), and increased reproducibility of data.
Integrating VR, Eye Tracking and Biofeedback in Research
Experts discuss and demonstrate how to set up and plan experiments combining virtual reality (VR) with real-time eye tracking and physiology data measurement.
SuperArgus PET/CT: Advanced Pre-Clinical Imaging for Small to Medium Animals
Tonya Coulthard discusses the SuperArgus PET/CT systems, reviewing both basic and unique imaging capabilities, including real-time imaging of awake animals as well as multiplexed PET imaging of standard and non-standard isotopes.
Ex Vivo MicroangioCT: Advances in Microvascular Imaging
Experts discuss a radiopaque polymerizing contrast agent that can be used to overcome the inherent challenges in distinguishing soft tissues with micro CT.
Open Access: What Researchers Need to Know Now
Industry professionals define what it means to publish Open Access, the different types, factors that influence funding, and share how to manage related fees from grants and budgets in several examples.
Eye Tracking and Mobile-Remote Participants
Experts demonstrate how to set up an eye tracking experiment and combine this data with physiological data such as ECG, EEG, EDA, EMG/fEMG and RSP.
Reversing Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic NHPs with a Controlled-Release Mitochondrial Protonophore (CRMP)
Leigh Goedeke, PhD reviews spontaneous nonhuman primate (NHP) models of NAFLD and metabolic syndrome as a more clinically-relevant preclinical study platform.
Remote Eye Tracking: Advanced Integration with Physiology Data
Experts discuss how to set up a remote eye tracking experiment, present stimuli, collect physiology data and analyze your results.
The Application of NMR for Drug Development and Manufacturing in a Good Manufacturing Practice Setting
Dr. Kerry Hughes, of Almac, discusses the application of NMR in the GMP setting to ensure continued high-quality performance of drug discovery workflows.
Odor delivery with the 220A Olfactometer from Aurora Scientific
TECH CAST
Chris Rand discusses the updated 200A Olfactometer from Aurora Scientific. He walks through setting up the system before sharing best practices, all while demonstrating the integral functions of the system.
How to Plan and Execute Contractile Measurements in Permeabilized Muscle Fibers
Experts discuss the A-to-Z of assessing muscle performance and contractile function in single muscle fibers.
Turn Away from Traditional Tethering and Towards a Better Method for Data Collection
Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.
ASO-Mediated DNM2 Knockdown for Centronuclear Myopathies
VIRTUAL POSTER
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
Harnessing EEG Methods to Improve Basic and Translational Research for CNS Disorders
Dr. Robert Gould and Mike Girand discuss methods and applications for the use of EEG as a highly translational biomarker for sleep, substance use disorder and CNS disorders.
The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear
VIRTUAL POSTER
The MRL/MpJ mouse strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
ULK2 is Essential for Degradation of Ubiquitinated Protein Aggregates and Homeostasis in Skeletal Muscle
VIRTUAL POSTER
Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.
Organize and Streamline Data Collection with DMC LabBook
TECH CAST
Matt Borkowski of Aurora Scientific discusses the latest software update for their Dynamic Muscle Control and Analysis Software, DMC LabBook.
Place Cell Mapping and Stress Monitoring in Head-Fixed Mice Navigating an Air-Lifted Homecage
Scientists present data on 2-photon imaging of hippocampal place cells and on stress monitoring in head-fixed awake behaving mice.
Understanding Physiological Mechanisms of Opioid Addiction: Advancements in CNS and Respiratory Endpoint Measurement
Experts discuss how opioids affect sleep and respiratory depression in preclinical mouse models.
Preclinical Obesity Research: Best Practice in Model Selection and Study Design
Fred Beasley, PhD discusses how to select the most appropriate animal models for your preclinical obesity studies.
An Introduction to Isolated Langendorff Heart: Experimental Considerations and Best Practices
Join Dr. Melanie White for a discussion on basic isolated Langendorff heart principles, key experimental design considerations, core technology requirements and best practice tips to support consistency and validation of your research.
Single-Cell Electrophysiology and 2-Photon Imaging in Awake Mice with 2D-Locomotion Tracking
Scientists present case studies featuring single-cell electrophysiology and 2-photon microscopy in head-fixed, behaving mice.
Recording Facial EMG with New Amplifier Technology
ON DEMAND
An essential webinar for researchers interested in recording facial electromyography (fEMG) to measure muscle activity associated with smiling and frowning.
EEG and Telemetry: Best Practices for Managing Large Data Sets to Investigate Key Aspects of Epilepsy in Rodent Models
This webinar is essential for researchers interested in the use of continuous EEG telemetry for seizure assessment in rodent epilepsy models.
How to Optimize Preclinical Diabetes Studies using Stress Free Methods in Non-Human Primates
Andrew Puca, PhD discusses techniques for optimizing preclinical diabetes research in spontaneously diabetic NHPs, with a focus on stress free assessments of glucose measurement and response using continuous glucose monitoring and the banana tolerance test.
fNIR Applications and Solutions
ON DEMAND
An essential webinar for scientists interested in functional Near-Infrared Optical Imaging (fNIR) technology and how they can use it for cognitive neuroscience research.
InsideAnswers: Techniques and Best Practices for Cardiomyocyte Isolation
INSIDE ANSWERS
Ronglih Liao, Davor Pavlovic and Matthew Ackers-Johnson address the most popular questions related to cardiomyocyte isolation, purification, culture and analysis.
Optimizing Event-related EDA to Better Understand Participant Responses
ON DEMAND
Join Frazer Findlay for an educational webinar on the measurement and analysis of event-related Electrodermal Activity (EDA)
What is hyperoxia, normoxia and hypoxia to cells: Why researchers should care about environmental oxygen and how it influences results
ON DEMAND
An educational webinar providing an overview of the effects of oxygen concentration during in vitro cell culturing and how to accurately determine and regulate O2 levels during experiments.
Preclinical Imaging with Fluorescence In Vivo Endomicroscopy
ON DEMAND
An educational webinar for researchers interested in laser confocal endomicroscopy, including fundamental theoretical and practical knowledge and a discussion on key capabilities and research applications of the technology.
WEBINAR SERIES – Preclinical Cardiovascular Science 2018
A webinar series focused on advances in technology, experimental design and laboratory methods in preclinical cardiovascular research.
How to Synchronize Participant Video With Physiology Data
ON DEMAND
An essential webinar for scientists interested in recording synchronized video with physiological measurements in human or animal research applications.
Experimental Considerations when Planning Chronic Models of Cardiovascular Disease in Rodents
ON DEMAND
Join Dr. Tim Hacker for a discussion on experimental design, strategy, technology, common challenges and best-practices associated with planning long-term, chronic models of cardiovascular disease in rodents.
Techniques and Best Practices for Cardiomyocyte Isolation
ON DEMAND
Ronglih Liao and Davor Pavlovic discuss techniques for isolating myocytes using both traditional and Langendorff-free methodologies, including key considerations, best practices and how to achieve and confirm optimal myocyte quality
Studying Smooth and Striated Muscle Function Using Advanced Tissue Bath Systems
ON DEMAND
Aaron Stupica and Keshari Thakali discuss techniques tissue bath myography and present a unique case study looking at the effect of maternal obesity on offspring perivascular adipose tissue and vascular function.
Maximizing Data Quality in Life Science Data Acquisition and Analysis
ON DEMAND
An exclusive webinar focused on best practices, technical considerations and expert advice to ensure quality data and research outcomes using ADInstruments PowerLab and LabChart.
From Mouse to Monkey: Revolutionizing Research via Preclinical Continuous Glucose Telemetry
ON DEMAND
Scientists present wireless glucose monitoring methodology, best practices, research findings, and discuss the power of continuous glucose profiles in obesity, diabetes and cardiovascular research.
Combining Telemetry and Ultrasound for Serial Investigation of Cardiovascular Function in Rats
ON DEMAND
Experts discuss a novel method of recording serial measurements of cardiac function in rodents using high-resolution ultrasound paired with implantable telemetry.
Measuring Tissue Perfusion and PO2 in Conscious Animals to Investigate Organ Failure
ON DEMAND
Experts present new, ground breaking research using the latest in fibre optic sensing technology to obtain dissolved oxygen and microvascular blood perfusion in models of Acute Kidney Injury (AKI).
Improving Preclinical and Clinical Regulatory Submissions Through Enhanced ECG Interval and Arrhythmia Assessment
ON DEMAND
Experts in preclinical and clinical ECG safety assessment discuss how advances in arrhythmia detection and concentration effects modelling improve study outcomes.
WEBINAR SERIES – Recording Neuronal Activity in Animal Models
A comprehensive overview of technology and methods for recording and analyzing extracellular action potentials, local field potentials and EEG in a variety of research models.
Utilizing Nerve Cuff Electrodes for in vivo Peripheral Nerve Research
ON DEMAND
Experts discuss novel cuff electrodes for in vivo peripheral nerve research, including the importance of electrode design, how to select the right cuff, implantation techniques and application results from nerve stimulation and blocking.
Wireless Recording Technologies for in vivo Electrophysiology in Conscious, Freely Behaving Non-Human Primates
ON DEMAND
Scientists discuss technological advancements and present novel application of new head-mounted, wireless sensors for neural recording and stimulation in conscious non-human primates.
WEBINAR SERIES – Advancements in Exercise Physiology, Sports Science and Biomechanics
An essential webinar series reviewing various technologies used to study exercise physiology, sports science and biomechanics in human subjects.
Advancements in Wireless Technology for Single Unit Electrophysiology Recording
ON DEMAND
Experts discuss new configurable wireless technologies for single unit electrophysiology recording in small and large animals, with a focus on applications, methodology, data outcomes, and the impact these devices will have in research involving untethered, naturally behaving subjects.
Understanding the Issues Affecting the Accuracy of Measuring Oxygen Consumption Utilizing Metabolic Carts
ON DEMAND
A presentation on key issues effecting the accuracy and reproducibility of measuring Oxygen Consumption, VO2, via indirect calorimetry utilizing Metabolic Carts, and best-practices for scientists to drive more consistent and precise measurements.
Advances in Sub-cellular and Cellular in vivo Imaging for Systems Biology
ON DEMAND
Peter Delaney reviews trends and technological advancements in the field of in vivo fluorescence imaging, with a focus on new applications and capabilities as realized by confocal fluorescence endomicroscopy and 3D automated optical sectioning.
Invasive Blood Pressure: fundamentals and best-practices for preclinical research
Tom Smith presents the fundamentals of invasive blood pressure measurements for preclinical research, including technical considerations and best-practices that lead to accurate and consistent results.
Recording High-Quality Metabolic Data in Humans
ON DEMAND
Frazer Findlay and William McMullen discuss new technology and methods for measuring metabolic data from human research participants
Pillar One: Kinesiological Electromyography – a practical guide to intelligent systems and assessment
ON DEMAND
Building on its popular Biomechanics 101 Introduction, Noraxon turns it attention to the fundamental pillar of biomechanics: electromyography, or EMG. This informative session covers signal origin, acquisition, processing and analysis for a comprehensive and practical understanding of EMG research and assessment.
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