Abstract coming soon! The Bodine laboratory is interested in identifying the mechanisms responsible for muscle atrophy and determining strategies for preventing atrophy or accelerating recovery following a period of muscle loss.
Join Patrick Schönleitner, PhD and Francisco Altamirano, PhD as they share their work involving simultaneous measurements of intracellular calcium, membrane voltage, and contractility of cardiomyocytes.
Dr. Charlotte Peterson and Dr. Jack Guralnik will discuss the challenges of sarcopenia. They will define the disease and provide an in depth overview of the underlying mechanisms of pathology. They will then share some potential therapeutic interventions and disease outcomes for patients.
Julio Ayala, PhD and Matthew Robinson, PhD share their research focusing on feeding behavior in mice and the effects of stress and exercise on metabolism. They will discuss neuronal activity and high-fat diets as well as mitochondrial remodeling and exercise training in mouse models of obesity.
Experts present key considerations in the design of rigorous preclinical studies in rodent models of muscular dystrophy, including animal model selection, assays and endpoints, and how your results can inform translation to the clinic.
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.