Understanding the Translational Value of PV Loops from Mouse to Man

Understanding the Translational Value of PV Loops from Mouse to Man

Dr. Navin Kapur presents a detailed look at how Pressure-Volume loops impact outcomes in basic research and clinical therapies.

In this exclusive webinar sponsored by Millar, Dr. Navin Kapur, Assistant Professor and Assistant Director of the Interventional Cardiology Center at Tufts Medical Center, discusses how PV loop data can translate over from mouse to man and provide a confident approach to evaluating drug studies, device validation and treatments outcomes. Hemodynamics and measurements of cardiac function from the research bench-top are presented along with findings from clinical research settings. Furthermore, Dr. Kapur provides perspective on how PV Loops can be used as a tool for the interventional cardiologist and during the evaluation of advanced heart failure.

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Navin K. Kapur, MD

Assistant Director,
Interventional Cardiology Center
Investigator, Molecular Cardiology Research Institute (MCRI)
Assistant Professor,
Tufts University School of Medicine

Dr. Kapur is Director of the Acute Circulatory Support Program and Associate Director of the Cardiac Catheterization Laboratory at Tufts Medical Center. His clinical expertise focuses on invasive hemodynamics, mechanical circulatory support, and interventional therapies for patients with advanced heart failure.

As Director of the Interventional Research Laboratories at Tufts Medical, Dr. Kapur’s translational research focuses on large animal models of acute and chronic heart failure, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction. His recent work has focused on the hypothesis that mechanically unloading the heart and delaying coronary reperfusion limits infarct size. This concept known as the ‘mechanical conditioning hypothesis’ has the potential to alter the paradigm of acute heart attack therapy and reduce the burden of ischemic heart failure.