Advancements in Wireless Technology for Single Unit Electrophysiology Recording

Advancements in Wireless Technology for Single Unit Electrophysiology Recording

Experts discuss new wireless technology for single unit electrophysiology recording in small and large animals, with a focus on methodology, data outcomes and the impact these devices will have in research involving naturally behaving subjects.

In this webinar sponsored by Neuralynx, Casey Stengel provides an introductory overview of Cube2: an all-in-one, wireless headstage and data acquisition system for neuronal research in freely moving, untethered subjects. He explains how Cube2 has been purpose built to enable the study of research animals in social environments by allowing multiple transmitters in the same area, pulling data to local drives.

Following, Dr. John A. Wolf from the University of Pennsylvania provides two case studies highlighting his work focused on long term chronic affects of traumatic brain injury, including the development of post traumatic epilepsy. Specifically, Dr. Wolf discusses application of a custom enclosure that can be mounted on the animal in its home cage (or behavioral space), and can record from 64 channels over 24 hours.

In the third section of this webinar, Dr Kari Hoffman from Vanderbilt University presents a case study where she describes the use of the Cube wireless systems for wireless multi-site recordings in freely-behaving macaques.  She discusses experimental design, common challenges, and shares preliminary data demonstrating the capabilities of Cube2 and future possibilities for studies involving non-human primates.

Key topics covered during this webinar included:

  • Recording data on multiple channels over long time periods
  • The benefits of using wireless headstage systems in social and complex environments
  • How Cube2 is enabling new experimental paradigms that until now were simply not possible

To watch the webinar on demand, please click the button and complete the registration form – you will gain immediate access to the webinar auditorium to watch the event.

Presentation Details:

  • 00:00 – 01:42:  Webinar Introduction
  • 01:47 – 13:10:  Introduction and overview of Cube2 [C. Stengel]
  • 13:18 – 18:36:  Case study – Electrophysiological Dysfunction after traumatic brain injury in rodents [J.A. Wolf]
  • 18:37 – 25:25:  Case study – Does traumatic brain injury lead to Epileptogenesis and post-traumatic epilepsy in pigs? [J.A. Wolf]
  • 25:29 – 32:22:  Chronic implantation procedure [K. Hoffman]
  • 32:23 – 39:52:  Cube proof of concept in freely moving Macaques [K. Hoffman]
  • 39:53 – 55:10:  Presenter Q&A Session

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Presenters:

Kari Hoffman, PhD

Associate Professor of Psychological Sciences
Vanderbilt University

Dr. Kari Hoffman is an Associate Professor in Psychological Sciences at Vanderbilt University. She received her PhD in Neuroscience from the University of Arizona, where her work pioneered chronically implanted multi-electrode arrays enabling high-density (576-electrode) recordings of neural populations in the macaque monkey. During her post-doctoral fellowship at the Max Planck Institute in Germany, she used multi-channel neuronal recordings in conjunction with non-invasive imaging techniques to understand the neural basis of face processing and multisensory integration. Her lab at York University in Toronto, Ontario is focused on discovering the dynamics and mechanisms of plasticity in neural ensembles during perception and memory in macaques. She is continuing this work in her new lab at Vanderbilt University. Dr. Hoffman has been recognized by the Alfred P. Sloan Foundation, the Ontario Ministry of Research and Innovation, the Alzheimer’s Association, and the Alzheimer’s Society (Canada), and she is leading a 5-site Brain Canada Multi-Investigator Research Initiative to modify neural dynamics in memory-related brain structures.

John A. Wolf, PhD

Assistant Professor of Neurosurgery
University of Pennsylvania

John’s laboratory focuses on the effects of traumatic brain injury on the limbic system, including the hippocampus, PFC, and amygdala. They are particularly interested in the changes in coding in these structures, as well as the interactions between them, in both cognition and emotional processing. John and his team of researchers are developing new targets of neuromodulation for these regions and their connections as well.

Keith A. “Casey” Stengel

Founder, President, CEO,
Neuralynx

Casey founded Neuralynx in 1993 after spending seven years in the neuroscience field as cofounder and VP of Engineering of BrainWave Systems. His extensive interactions and hours spent in the lab with leading neuroscientists over 30 years makes him uniquely qualified to predict future trends, guiding the Company’s product line vision and development with forward thinking, cutting-edge innovation. Casey’s longtime, personal relationships with top neuroscientists, teaching hospital department heads and Nobel Prize laureates in both the animal and clinical research communities has resulted in key collaborations, further impacting the Company’s product roadmap strategies with disruptive technology ideas and development plans. His lifetime of electronics experience with both software and hardware development has consistently produced intuitive, customizable electrophysiology solutions with proven longevity and research results.