How to Investigate Behavior and Cognitive Abilities of Individual Rodents in a Social Group

How to Investigate Behavior and Cognitive Abilities of Individual Rodents in a Social Group

Experts provide insight into high-throughput cognition testing of individual rodents within their social environment, discussing how this supports increased animal welfare and decreased data variability and workload for the researcher. 

During this exclusive webinar sponsored by, TSE Systems, Drs. Ewelina Knapska, David Wolfer, and Holger Russig review automated home-cage behavioral phenotyping using the IntelliCage system and discuss several research applications including the study of hippocampus-dependent spatial learning tasks, measuring motor impulsivity, studying the role of MMP-9 in the central amygdala in learning of appetitively and aversively motivated behaviors, and assessing cognitive rigidity in a mouse models of autism.

After establishing basic concepts, presenters demonstrate how freely programmable behavioral tasks can be controlled and how to link them to established paradigms performed in biomedical and basic behavioral, neurobiological, psychiatric, pharmacological and genetic research. The implications for understanding therapeutic strategies is also discussed.

Key topics in this webinar include…

  • how to transfer concepts of established behavioral paradigms into an automated home-cage
  • simultaneous monitoring of different mouse behaviors
  • comparing different behaviors in well-balanced conditions
  • the involvement of MMP-9 in the central amygdala in learning of appetitively and aversively motivated behaviors
  • prescreening of subjects using spontaneous behavior during adaptation to optimize cognitive tests
  • hippocampus-dependent spatial learning tasks

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Presenters:

David P. Wolfer, MD

Associate Professor of Anatomy,
Institute of Anatomy,
University of Zurich

Ewelina Knapska, PhD

Laboratory of Emotions Neurobiology,
Nencki Institute of Experimental Biology

Holger Russig, PhD

Scientific Officer,
TSE Systems Inc.