A special webinar for basic cardiovascular researchers interested in a novel technique for measuring work output and replicating the four phases of the cardiac cycle at the single cell level.

The study of isolated cardiac myocytes provide a wealth of basic cellular and molecular information without the complications often associated with heterogeneous multicellular preparations. The overwhelming majority of data presented in myocyte studies, however, are reported in mechanically unloaded conditions. Join us for a practical demonstration of an exciting new technique where mechanical control of the cell reveals the myocyte’s force-length relationship by varying pre- and afterload to achieve isometric, isotonic, and, ultimately, work-loop style contractions analogous to the pressure-volume relationship in whole heart studies.

In this exclusive webinar sponsored by IonOptix, Michiel Helmes presents methodology and best-practices that scientists should follow in order to replicate the cardiac cycle in an isolated cardiomyocyte. He discusses how this research method can be used to better address contractile function in cardiovascular disease studies and highlight critical features of the IonOptix MyoStretcher system that are important for this emerging and novel technique.

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Dr. Michiel Helmes has been able to successfully combine academia with an industrial career. After his PhD studying titin mechanics in cardiac muscle with Dr. Granzier, he has kept various academic appointments, at Boston University, the University of Oxford, and now the VU University Medical center in Amsterdam, The Netherlands. He is part owner and involved in system development at Ionoptix LLC. Being so fully immersed in working with isolated cardiac myocytes, he reached the conclusion that the field needed a more standardized instrument, and in 2015 he set up Cytocypher, that developed the high throughput system for calcium/contractility measurements that is the subject of this webinar.

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