In this webinar, Max Haberbusch, PhD and Esra Neufeld, PhD explore closed-loop cardiac rhythm control restoration in heart-transplant patients from model development to in silico regulatory evidence for safety and efficacy trials.

The NIH SPARC program pursues the ambitious goal to rapidly advance the promising field of bioelectronic medicine. This not only includes funding over 100 research teams to perform comprehensive mapping of the autonomic peripheral nervous system and its interaction with organ physiology, but also establishes a large infrastructure for FAIR data sharing, collaborative and reproducible modeling, mapping and knowledge management, to supercharge the field.

After briefly introducing SPARC and its infrastructure, this webinar illustrates how the NeuHeart consortium – an independent European research initiative – has leveraged that infrastructure in its quest to restore closed-loop cardiac rhythm control to heart-transplant patients.

The webinar discusses:

  1. Hybrid electromagnetic (EM-)electrophysiological modeling of neural interfaces, including model-based stimulation selectivity optimization and neural sensing information content maximization;
  2. A comprehensive model of cardiovascular regulation and its experimental validation; and
  3. Integration of these independently developed neural interface and cardiovascular regulation models, along with a generic closed-loop control framework.

The end provides a view on the ongoing research on model-based intelligent control and in silico regulatory evidence and trials for safety and efficacy assessment.

Key Topics Include:

  • The dynamics of cardiovascular regulation after heart transplantation
  • The development of therapeutic bioelectronic devices for information-maximized sensing and selective stimulation
  • Model-based control of neural interfaces
  • Open and FAIR neurosciences, with a particular focus on reproducible, sustainable, and integrative computational modeling (illustrated through the integration of independently developed neural interface and cardiovascular regulation models)


Postdoctoral Associate
Center for Medical Physics and Biomedical Engineering
Medical University of Vienna

Max Haberbusch, PhD is an enthusiastic academic who has made significant contributions to the field of vagus nerve stimulation for cardiac applications. Currently serving as a postdoc at the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Dr. Haberbusch is involved in investigating the development and simulation of cardiovascular devices and hemodynamics for diagnostic and therapeutic tools in the field of cardiovascular dynamics.

Associate Director and Head
Computational Life Sciences
IT’IS Foundation

Esra Neufeld, PhD is the Associate Director and Head of Computational Life Sciences at the IT’IS Foundation in Zurich where he is responsible for the development of the multi-physics simulation platform Sim4Life. As a founding member of the SPARC Data and Resource Center, IT’IS develops and maintains o2S2PARC, a comprehensive, intuitive, freely accessible online platform to simulate and study nerve electrophysiology and its interaction with organ physiology in a precise and predictive manner.

Production Partner

SPARC Data and Resource Centre

The NIH Common Fund’s Stimulating Peripheral Activity to Relieve Conditions (SPARC) program aims to transform our understanding of nerve-organ interactions with the intent of advancing bioelectronic medicine towards treatments that change lives. The overall vision for the SPARC Portal is to accelerate autonomic neuroscience research and device development by providing access to digital resources that can be shared, cited, visualized, computed, and used for virtual experimentation.

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