In this webinar, Max Haberbusch, PhD and Esra Neufeld, PhD explore closed-loop cardiac rhythm control restoration in heart-transplant patients from model development to in silico regulatory evidence for safety and efficacy trials.
The NIH SPARC program pursues the ambitious goal to rapidly advance the promising field of bioelectronic medicine. This not only includes funding over 100 research teams to perform comprehensive mapping of the autonomic peripheral nervous system and its interaction with organ physiology, but also establishes a large infrastructure for FAIR data sharing, collaborative and reproducible modeling, mapping and knowledge management, to supercharge the field.
After briefly introducing SPARC and its infrastructure, this webinar will illustrate how the NeuHeart consortium – an independent European research initiative – has leveraged that infrastructure in its quest to restore closed-loop cardiac rhythm control to heart-transplant patients.
The webinar will discuss:
- Hybrid electromagnetic (EM-)electrophysiological modeling of neural interfaces, including model-based stimulation selectivity optimization and neural sensing information content maximization;
- A comprehensive model of cardiovascular regulation and its experimental validation; and
- Integration of these independently developed neural interface and cardiovascular regulation models, along with a generic closed-loop control framework.
It will end with a view on the ongoing research on model-based intelligent control and in silico regulatory evidence and trials for safety and efficacy assessment.
Key Topics Include:
- The dynamics of cardiovascular regulation after heart transplantation
- The development of therapeutic bioelectronic devices for information-maximized sensing and selective stimulation
- Model-based control of neural interfaces
- Open and FAIR neurosciences, with a particular focus on reproducible, sustainable, and integrative computational modeling (illustrated through the integration of independently developed neural interface and cardiovascular regulation models)
Presenters
Postdoctoral Associate
Center for Medical Physics and Biomedical Engineering
Medical University of Vienna
Max Haberbusch, PhD is an enthusiastic academic who has made significant contributions to the field of vagus nerve stimulation for cardiac applications. Currently serving as a postdoc at the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Dr. Haberbusch is involved in investigating the development and simulation of cardiovascular devices and hemodynamics for diagnostic and therapeutic tools in the field of cardiovascular dynamics.
Associate Director and Head
Computational Life Sciences
IT’IS Foundation
Esra Neufeld, PhD is the Associate Director and Head of Computational Life Sciences at the IT’IS Foundation in Zurich where he is responsible for the development of the multi-physics simulation platform Sim4Life. As a founding member of the SPARC Data and Resource Center, IT’IS develops and maintains o2S2PARC, a comprehensive, intuitive, freely accessible online platform to simulate and study nerve electrophysiology and its interaction with organ physiology in a precise and predictive manner.
Production Partner
SPARC Data and Resource Centre
The NIH Common Fund’s Stimulating Peripheral Activity to Relieve Conditions (SPARC) program aims to transform our understanding of nerve-organ interactions with the intent of advancing bioelectronic medicine towards treatments that change lives. The overall vision for the SPARC Portal is to accelerate autonomic neuroscience research and device development by providing access to digital resources that can be shared, cited, visualized, computed, and used for virtual experimentation.
Additional Content From American Physiological Society
Impact of Sleep and Circadian Disruption on Human Health and Disease Risk
Join Josiane Broussard, PhD as she explains the links between sleep and circadian disruption and cardiovascular and metabolic health.
Cut and Paste of Myosin Binding Protein-C in Striated Muscles
Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Evaluation of Novel Therapies Using Spontaneous Seizure Models
In this webinar, Dr. Cameron Metcalf covers the technical requirements and benefits of spontaneous seizure models, addressing the challenges and optimization of 24/7 video-EEG data collection for epilepsy therapy development.
Additional Content From Society for Neuroscience
Implantable Circuit-Specific Treatments for Cardiovascular Dysfunction
In this webinar, Dr. Aaron Phillips will present his research on the neural mechanisms of hemodynamic stability.
Systemic and Intraspinal Pathology and Repair After Spinal Cord Injury in Rodents
Join Dana McTigue for a deep dive into her work studying spinal cord injury in rodents and its resulting pathological features in lower organs.
Cellular Brain Repair for Parkinson’s Disease: Is the Answer in the (Biomaterial) Matrix?
Join Eilís Dowd, PhD who will highlight her lab's recent data demonstrating that dopaminergic cell replacement in the Parkinsonian rodent brain, using both fetal and induced stem cell-derived cells, is enhanced when the cells are transplanted in a neurotrophin-enriched collagen hydrogel.
Additional Content From Federation of European Neuroscience Societies
Measuring Neuronal Activity and Vascular Physiology in the Human Brain Using High-Resolution Functional Magnetic Resonance Imaging
Join Jonathan Polimeni, PhD for a deep dive into the physics and physiology of fMRI.
Compensatory Mechanisms in Parkinson’s Disease
Bas Bloem, MD will review compensatory mechanisms, including cerebral plasticity and behavioral adaptation, in persons with Parkinson's disease.
New Horizons: Gonadotropin-Releasing Hormone and Cognition
Join Vincent Prevot, PhD as he dives into the development and establishment of the gonadotropin-releasing hormone (GnRH) system and the importance of its first postnatal activation.
Additional Content From American Autonomic Society
Autonomic Regulation of Metabolic and Cardiovascular Functions in Health and Disease
In this webinar, Dr. Rahmouni presents his research on the fundamental processes mediating autonomic nervous system control of energy homeostasis and cardiovascular function in health and disease.
Integrative Physiological Responses to Exercise-Heat Stress: Sex as a Biological Variable
Watch Nisha Charkoudian, PhD for the first event in the 2023 Neurophysiology Series as she summarizes the integrative physiology of responses to exercise-heat stress and discusses implications for athletes and the military.
Additional Content From Scientist.com
Exploring Predictive Biomarkers and ERK1/2 Phosphorylation: A New Horizon in Forecasting Survival and Response to Immune Checkpoint Blockade in Glioblastoma Treatment
In this webinar, Victor Arrieta highlights the link between p-ERK activation and improved survival in rGBM patients using anti-PD-1 immunotherapy.
Advancing Water Quality Monitoring: How to Easily Integrate Advanced Bioanalytical Techniques for Comprehensive Insights
Dr. Jack Vanden Heuvel discusses how integrating cell-based bioassays and effect-based trigger values enhances water quality assessment beyond traditional methods.
Revolutionizing Immunotherapy Research with 3D, Multiplexed Cryo-fluorescence Tomography
Dr. Matt Silva showcases the power of cryo-fluorescence tomography (CFT) in advancing immunotherapy research.
Related Content
Symposium: Opportunities, Hopes, and Challenges in Translating Visual Restoration from Mouse to Human
Striatech celebrates its 5th anniversary with a top-class Symposium on the topic of translating visual restoration from mouse to human.
Fully Characterized, Standardized Human Induced Pluripotent Stem Cell Line and Ready-to-Use, High-Quality Neural Progenitor Cells for Downstream Differentiation Applications
In this webinar, experts present a standardized human induced pluripotent stem cell line and its differentiation into neural cells for disease modeling and assay development.
Real-time IntraVital Microscopy (IVM): In Vivo Live Cell Imaging in Immunology and Neuroscience with Live Imaging Demo
Selina Soyeon Ahn, PhD introduces IVIM Technology’s All-in-One real-time intravital confocal and two-photon microscopy system and its application to immunology and neuroscience research.