Making Optical and Electrophysiological Measurements in the Brain of Head-Fixed, Freely-Moving Rodents

Making Optical and Electrophysiological Measurements in the Brain of Head-Fixed, Freely-Moving Rodents

The must-watch webinar for researchers interested in optical and electrophysiological recordings from the brain of head-fixed but otherwise freely moving rodents.

A growing number of researchers are moving from reduced preparations such as dissociated cultured neurons or brain slices, to experimentation in live animals – in vivo – using advanced methods such as two-photon microscopy or combined optogenetics and patch-clamp recordings. In order to immobilize the animal during these challenging applications general anesthesia is often administered; however, the use of anesthetics greatly distorts brain function.
Is there a better way?

In this exclusive webinar sponsored by Neurotar Ltd., leading experts in the technology discuss methodology, best-practices and show attendees how to immobilize the rodent’s head without restraining its body using the Mobile HomeCage™. The result is a controlled research environment for studying brain function in awake, freely-moving subjects with no stress to the animal. Discussion around how this technique can be applied to the study of neuronal plasticity, neurodegeneration, addiction, brain trauma and other pathophysiological conditions in longitudinal experiments was included.

To access the webinar recording, please click the button and complete the registration form — once authorized the video will load in a separate viewing window.

To download a PDF copy of the presentation, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.

Presenters:

Eero Castren, MD PhD

University of Helsinki

Petri Hyytia, PhD

University of Helsinki

Leonard Khiroug, PhD

Neurotar Ltd.