Measuring Force in Single Heart Cells

Measuring Force in Single Heart Cells

New technology now provides investigators the ability to reliably attach myocytes, mechanically stretch them, make direct force measurements and control cell length intelligently. This webinar reviews best-practices and techniques for attaching, stretching, and studying isolated cells.

During this exclusive webinar sponsored by IonOptix, presenters Ben Prosser and Michiel Helmes discuss methodology, best-practices, and show attendees how to attach isolated myocytes to ensure accurate force measurements. In addition, Ben Prosser reviews an application of myocyte stretching and loading. Michiel Helmes discusses the importance of both mechanical loading and measuring force, and how controlling myocyte length to regulate force development enables generation of work loops and a host of mechanical studies.

Key topics in this webinar include…

  • Why it is important to mechanically load single myocytes and how to do master the technique
  • The value of measuring force in single cell applications of cardiac function research
  • Why it is important to control myocyte length
  • The value of combining force measurements with other indices of contraction and cellular function

Click to watch the webinar recording. To view the presentation full screen simply click the square icon located in the bottom-right corner of the video-viewer.

To download a PDF copy of the presentation, click on the “LinkedIn SlideShare” icon located in the bottom-right corner of the slide-viewer. From the SlideShare landing page click the “Download” button to retrieve the file.

Benjamin L. Prosser, PhD

Assistant Professor,
Department of Physiology
Perelman School of Medicine
University of Pennsylvania

Michiel Helmes, PhD

Department of Physiology
VU University Medical Center Amsterdam
& IonOptix