Join Scott Hall, PhD as he presents his research that focuses on treatments for impulsive behavior commonly associated with Attention Deficit Hyperactivity Disorder (ADHD).

Substantial evidence has shown that dopamine transporter knockout (DAT KO) mice constitute an animal model of Attention Deficit Hyperactivity Disorder (ADHD). DAT -/- mice are hyperactive, show deficits in preattentional processes (e.g. sensorimotor gating), and have impaired executive function. DAT +/- mice show only limited deficits in the same behavioral tests. In examining more complex cognitive tasks using a 5-Choice apparatus, DAT -/- mice were found to be so behaviorally impaired that they could not learn even basic responding. Their attentional focus was solely oriented towards the food panel so that they failed to observe the lights behind them. DAT +/- were capable of learning the task and showed evidence of impulsive behavior in the 5-Choice Continuous Performance Task (5-Choice CPT).

This impulsive behavior was eliminated by treatment with the known ADHD medication atomoxetine, as well as with the putative ADHD treatment SB 224289, a serotonin 5-HT1B antagonist that was previously found to reduce many of the impairments found in DAT -/- mice. These data provide evidence that DAT +/- mice show ADHD like deficits that may provide a better model of ADHD than DAT -/- mice, and further support the potential of 5-HT1B antagonists to reduce impulsive behavior.

Presenters

Associate Professor
College of Pharmacy and Pharmaceutical Sciences
University of Toledo

Dr. F. Scott Hall is an Associate Professor of Pharmacology and Experimental Therapeutics in the College of Pharmacy and Pharmaceutical Sciences at the University of Toledo. His research has focused primarily upon the genetic basis of addiction and the role that early social experience plays in shaping adult behavior and behavioral pathology. After a B.A. from Harvard University (1987) and a Ph.D. from the University of Cambridge (1994), he completed a National Research Council Research Associateship at the National Institute on Alcoholism and Alcohol Abuse. His research at NIAAA focused on animal models of schizophrenia and alcohol use disorder. He joined the Molecular Neurobiology Branch at the National Institute on Drug Abuse in 1999 where he led a behavioral genetics group in the Molecular Neurobiology Branch until 2014, when he moved to the University of Toledo. Dr. Hall’s laboratory at the University of Toledo investigates the genetic and environmental determinants of susceptibility to addiction and related psychiatric disorders.

Production Partner

Panlab S.L.U.

With more than 45 years’ experience in research instrumentation, Panlab and Coulbourn Instruments offer a comprehensive range of flexible and straightforward solutions for the automated evaluation of behavior in small laboratory animals. Quality and reliable tools for filling both standard and advanced needs in Neuroscience, Metabolism and Cardiovascular research: video-tracking, mazes, operant/behavior chambers, fear conditioning and startle test, rota rods, treadmills, indirect calorimetry and much more.

Coulbourn Instruments

With more than 45 years’ experience in research instrumentation, Coulbourn Instruments and Panlab offer a comprehensive range of flexible and straightforward solutions for the automated evaluation of behavior in small laboratory animals. Quality and reliable tools for filling both standard and advanced needs in Neuroscience, Metabolism and Cardiovascular research: video-tracking, mazes, operant/behavior chambers, fear conditioning and startle test, rota rods, treadmills, indirect calorimetry and much more.

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